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Literature summary extracted from

  • Dangkulwanich, M.; Raetz, C.R.H.; Williams, A.H.
    Structure guided design of an antibacterial peptide that targets UDP-N-acetylglucosamine acyltransferase (2019), Sci. Rep., 9, 3947 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.129 expression in Escherichia coli Escherichia coli

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.129 in complex with inhibitor peptide WMLDPIAGKWSR, to 1.6 A resolution. The peptide is located at the interface of each adjacent subunit and interacts with residues from both sides. It occupies part of the ACP binding site Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.129 WMLDPIAGKWSR
-
 Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.129 Escherichia coli P0A722
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.129 (R)-3-hydroxydodecanoyl-[acyl-carrier protein] + UDP-N-acetyl-alpha-D-glucosamine
-
 Escherichia coli [acyl-carrier protein] + UDP-3-O-(3-hydroxydodecanoyl)-N-acetyl-alpha-D-glucosamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.129 LpxA
-
 Escherichia coli

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.129 0.00005
-
 pH 8.0, 30°C Escherichia coli WMLDPIAGKWSR