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Literature summary extracted from

  • Pan, Q.; Zhao, F.; Ye, B.
    Eis, a novel family of arylalkylamine N-acetyltransferase (EC 2.3.1.87) (2018), Sci. Rep., 8, 2435 .
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.87 0.066
-
 propionyl-CoA cosubstrate octopamine, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 0.098
-
 propionyl-CoA cosubstrate tyramine, pH 7.0, 25°C Mycolicibacterium smegmatis
2.3.1.87 0.12
-
 acetyl-CoA cosubstrate histamine, pH 7.0, 25°C Mycobacterium tuberculosis
2.3.1.87 0.27
-
 acetyl-CoA cosubstrate tyramine, pH 7.0, 25°C Mycolicibacterium smegmatis
2.3.1.87 0.47
-
 propionyl-CoA cosubstrate histamine, pH 7.0, 25°C Mycobacterium tuberculosis
2.3.1.87 0.48
-
 acetyl-CoA cosubstrate octopamine, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 0.94
-
 octopamine cosubstrate acetyl-CoA, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 2.8
-
 histamine cosubstrate acetyl-CoA, pH 7.0, 25°C Mycobacterium tuberculosis
2.3.1.87 4.3
-
 tryptamine cosubstrate acetyl-CoA, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 6.2
-
 octopamine cosubstrate acetyl-CoA, pH 7.0, 25°C Mycobacterium tuberculosis
2.3.1.87 11
-
 dopamine cosubstrate acetyl-CoA, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 11
-
 Phenylethylamine cosubstrate acetyl-CoA, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 13
-
 serotonin cosubstrate acetyl-CoA, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 16
-
 histamine cosubstrate acetyl-CoA, pH 7.0, 25°C Mycolicibacterium smegmatis
2.3.1.87 30
-
 octopamine cosubstrate acetyl-CoA, pH 7.0, 25°C Mycolicibacterium smegmatis
2.3.1.87 57
-
 tyramine cosubstrate acetyl-CoA, pH 7.0, 25°C Saccharopolyspora erythraea

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.87 Mycobacterium tuberculosis P9WFK7
-
-
2.3.1.87 Mycobacterium tuberculosis ATCC 25618 P9WFK7
-
-
2.3.1.87 Mycolicibacterium smegmatis A0QY29
-
-
2.3.1.87 Mycolicibacterium smegmatis ATCC 700084 A0QY29
-
-
2.3.1.87 Saccharopolyspora erythraea
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.87 acetyl-CoA + dopamine
-
 Saccharopolyspora erythraea CoA + N-acetyldopamine
-
 ?
2.3.1.87 acetyl-CoA + histamine
-
 Mycobacterium tuberculosis CoA + N-acetylhistamine
-
 ?
2.3.1.87 acetyl-CoA + histamine
-
 Mycobacterium tuberculosis ATCC 25618 CoA + N-acetylhistamine
-
 ?
2.3.1.87 acetyl-CoA + octopamine
-
 Saccharopolyspora erythraea CoA + N-acetyloctopamine
-
 ?
2.3.1.87 acetyl-CoA + octopamine
-
 Mycobacterium tuberculosis CoA + N-acetyloctopamine
-
 ?
2.3.1.87 acetyl-CoA + octopamine
-
 Mycolicibacterium smegmatis CoA + N-acetyloctopamine
-
 ?
2.3.1.87 acetyl-CoA + octopamine
-
 Mycolicibacterium smegmatis ATCC 700084 CoA + N-acetyloctopamine
-
 ?
2.3.1.87 acetyl-CoA + octopamine
-
 Mycobacterium tuberculosis ATCC 25618 CoA + N-acetyloctopamine
-
 ?
2.3.1.87 acetyl-CoA + phenylethylamine
-
 Saccharopolyspora erythraea CoA + N-acetylphenylethylamine
-
 ?
2.3.1.87 acetyl-CoA + serotonin
-
 Saccharopolyspora erythraea CoA + N-acetylserotonin
-
 ?
2.3.1.87 acetyl-CoA + tryptamine
-
 Saccharopolyspora erythraea CoA + N-acetyltryptamine
-
 ?
2.3.1.87 acetyl-CoA + tyramine
-
 Saccharopolyspora erythraea CoA + N-acetyltyramine
-
 ?
2.3.1.87 acetyl-CoA + tyramine
-
 Mycolicibacterium smegmatis CoA + N-acetyltyramine
-
 ?
2.3.1.87 acetyl-CoA + tyramine
-
 Mycolicibacterium smegmatis ATCC 700084 CoA + N-acetyltyramine
-
 ?
2.3.1.87 propionyl-CoA + histamine
-
 Mycobacterium tuberculosis CoA + N-propionylhistamine
-
 ?
2.3.1.87 propionyl-CoA + histamine
-
 Mycolicibacterium smegmatis CoA + N-propionylhistamine
-
 ?
2.3.1.87 propionyl-CoA + histamine
-
 Mycolicibacterium smegmatis ATCC 700084 CoA + N-propionylhistamine
-
 ?
2.3.1.87 propionyl-CoA + histamine
-
 Mycobacterium tuberculosis ATCC 25618 CoA + N-propionylhistamine
-
 ?
2.3.1.87 propionyl-CoA + tyramine
-
 Saccharopolyspora erythraea CoA + N-propionyltyramine
-
 ?
2.3.1.87 propionyl-CoA + tyramine
-
 Mycolicibacterium smegmatis CoA + N-propionyltyramine
-
 ?
2.3.1.87 propionyl-CoA + tyramine
-
 Mycolicibacterium smegmatis ATCC 700084 CoA + N-propionyltyramine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.87 Eis
-
 Saccharopolyspora erythraea
2.3.1.87 Eis
-
 Mycobacterium tuberculosis
2.3.1.87 Eis
-
 Mycolicibacterium smegmatis
2.3.1.87 MSMEG_3513
-
 Mycolicibacterium smegmatis
2.3.1.87 Rv2416c
-
 Mycobacterium tuberculosis

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.3.1.87 0.48
-
 histamine cosubstrate acetyl-CoA, pH 7.0, 25°C Mycolicibacterium smegmatis
2.3.1.87 0.5
-
 histamine cosubstrate acetyl-CoA, pH 7.0, 25°C Mycobacterium tuberculosis
2.3.1.87 0.6
-
 propionyl-CoA cosubstrate histamine, pH 7.0, 25°C Mycobacterium tuberculosis
2.3.1.87 1.5
-
 serotonin cosubstrate acetyl-CoA, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 1.8
-
 octopamine cosubstrate acetyl-CoA, pH 7.0, 25°C Mycobacterium tuberculosis
2.3.1.87 2.3
-
 propionyl-CoA cosubstrate octopamine, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 2.7
-
 propionyl-CoA cosubstrate tyramine, pH 7.0, 25°C Mycolicibacterium smegmatis
2.3.1.87 2.8
-
 dopamine cosubstrate acetyl-CoA, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 3
-
 tryptamine cosubstrate acetyl-CoA, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 3.1
-
 octopamine cosubstrate acetyl-CoA, pH 7.0, 25°C Mycolicibacterium smegmatis
2.3.1.87 4
-
 octopamine cosubstrate acetyl-CoA, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 5.6
-
 acetyl-CoA cosubstrate histamine, pH 7.0, 25°C Mycobacterium tuberculosis
2.3.1.87 7.2
-
 Phenylethylamine cosubstrate acetyl-CoA, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 18
-
 tyramine cosubstrate acetyl-CoA, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 29
-
 acetyl-CoA cosubstrate tyramine, pH 7.0, 25°C Mycolicibacterium smegmatis
2.3.1.87 38
-
 acetyl-CoA cosubstrate octopamine, pH 7.0, 25°C Saccharopolyspora erythraea

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.3.1.87 0.033
-
 histamine cosubstrate acetyl-CoA, pH 7.0, 25°C Mycolicibacterium smegmatis
2.3.1.87 0.12
-
 serotonin cosubstrate acetyl-CoA, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 0.17
-
 histamine cosubstrate acetyl-CoA, pH 7.0, 25°C Mycobacterium tuberculosis
2.3.1.87 0.28
-
 dopamine cosubstrate acetyl-CoA, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 0.33
-
 octopamine cosubstrate acetyl-CoA, pH 7.0, 25°C Mycobacterium tuberculosis
2.3.1.87 0.37
-
 tyramine cosubstrate acetyl-CoA, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 0.43
-
 octopamine cosubstrate acetyl-CoA, pH 7.0, 25°C Mycolicibacterium smegmatis
2.3.1.87 0.67
-
 Phenylethylamine cosubstrate acetyl-CoA, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 0.73
-
 tryptamine cosubstrate acetyl-CoA, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 4.4
-
 octopamine cosubstrate acetyl-CoA, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 14
-
 propionyl-CoA cosubstrate histamine, pH 7.0, 25°C Mycobacterium tuberculosis
2.3.1.87 29
-
 propionyl-CoA cosubstrate tyramine, pH 7.0, 25°C Mycolicibacterium smegmatis
2.3.1.87 39
-
 propionyl-CoA cosubstrate octopamine, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 52
-
 acetyl-CoA cosubstrate histamine, pH 7.0, 25°C Mycobacterium tuberculosis
2.3.1.87 91
-
 acetyl-CoA cosubstrate octopamine, pH 7.0, 25°C Saccharopolyspora erythraea
2.3.1.87 110
-
 acetyl-CoA cosubstrate tyramine, pH 7.0, 25°C Mycolicibacterium smegmatis