Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ohshiro, T.; Kobayashi, K.; Ohba, M.; Matsuda, D.; Rudel, L.L.; Takahashi, T.; Doi, T.; Tomoda, H.
    Selective inhibition of sterolO-acyltransferase 1 isozyme by beauveriolide III in intact cells (2017), Sci. Rep., 7, 4163 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.26 expression in CHO cell Homo sapiens
2.3.1.26 expression in CHO cell Chlorocebus aethiops

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.26 beauveriolide I selectively inhibits isoform SOAT1 in a cell-based assay, and shows dual inhibition of SOAT1 and SOAT2 in the enzyme-based assay Chlorocebus aethiops
2.3.1.26 beauveriolide I selectively inhibits isoform SOAT1 in a cell-based assay, and shows dual inhibition of SOAT1 and SOAT2 in the enzyme-based assay Homo sapiens
2.3.1.26 beauveriolide III selectively inhibits isoform SOAT1 in a cell-based assay, and shows dual inhibition of SOAT1 and SOAT2 in the enzyme-based assay . Beauveriolide III binds to a putative active site responsible for SOAT1 that is located on the cytosolic side of the ER, while Beauveriolide III is not accessible to the corresponding active site for SOAT2 located on the luminal side Chlorocebus aethiops
2.3.1.26 beauveriolide III selectively inhibits isoform SOAT1 in a cell-based assay, and shows dual inhibition of SOAT1 and SOAT2 in the enzyme-based assay . Beauveriolide III binds to a putative active site responsible for SOAT1 that is located on the cytosolic side of the ER, while Beauveriolide III is not accessible to the corresponding active site for SOAT2 located on the luminal side Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Chlorocebus aethiops O77760 isoform SOAT1
-
2.3.1.26 Homo sapiens P35610
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 oleoyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesterol oleate
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol
-
 Chlorocebus aethiops CoA + cholesterol oleate
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.26 0.00051
-
 cell-based assay, pH 7.2, 37°C Homo sapiens beauveriolide III
2.3.1.26 0.0006
-
 cell-based assay, pH 7.2, 37°C Chlorocebus aethiops beauveriolide III
2.3.1.26 0.00061
-
 cell-based assay, pH 7.2, 37°C Homo sapiens beauveriolide I
2.3.1.26 0.0009
-
 cell-based assay, pH 7.2, 37°C Chlorocebus aethiops beauveriolide I
2.3.1.26 0.0012
-
 enzyme-based assay, pH 7.2, 37°C Homo sapiens beauveriolide III
2.3.1.26 0.0012
-
 enzyme-based assay, pH 7.2, 37°C Chlorocebus aethiops beauveriolide III
2.3.1.26 0.003
-
 enzyme-based assay, pH 7.2, 37°C Chlorocebus aethiops beauveriolide I
2.3.1.26 0.0032
-
 enzyme-based assay, pH 7.2, 37°C Homo sapiens beauveriolide I