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Literature summary extracted from

  • Samant, S.; Kanwal, A.; Pillai, V.; Bao, R.; Gupta, M.
    The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy (2017), Sci. Rep., 7, 11744 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.B41 NAD+ + [protein]-N6-palmitoyl-L-lysine Homo sapiens
-
 nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?
2.3.1.B41 NAD+ + [protein]-N6-palmitoyl-L-lysine Mus musculus
-
 nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.B41 Homo sapiens Q8N6T7
-
-
2.3.1.B41 Mus musculus P59941
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.B41 C2C12 cell
-
 Mus musculus
-
2.3.1.B41 cardiac muscle fiber
-
 Homo sapiens
-
2.3.1.B41 cardiac muscle fiber
-
 Mus musculus
-
2.3.1.B41 heart
-
 Homo sapiens
-
2.3.1.B41 heart
-
 Mus musculus
-
2.3.1.B41 muscle fibre
-
 Homo sapiens
-
2.3.1.B41 muscle fibre
-
 Mus musculus
-
2.3.1.B41 skeletal muscle
-
 Homo sapiens
-
2.3.1.B41 skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.B41 NAD+ + [protein]-N6-palmitoyl-L-lysine
-
 Homo sapiens nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?
2.3.1.B41 NAD+ + [protein]-N6-palmitoyl-L-lysine
-
 Mus musculus nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.B41 histone deacetylase
-
 Homo sapiens
2.3.1.B41 histone deacetylase
-
 Mus musculus
2.3.1.B41 NAD+-dependent lysine deacylase
-
 Homo sapiens
2.3.1.B41 NAD+-dependent lysine deacylase
-
 Mus musculus
2.3.1.B41 SIRT6
-
 Homo sapiens
2.3.1.B41 SIRT6
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.B41 NAD+
-
 Homo sapiens
2.3.1.B41 NAD+
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.3.1.B41 evolution there are seven evolutionarily conserved mammalian sirtuins (SIRT1-7) distributed to different compartments of the cell. They possess different deacylation activities to post-translationally modulate functions of their targets influencing major cellular pathways. SIRT6 is associated with chromatin and possesses histone deacetylase as well as mono-ADP-ribosylase activities, for both of which it needs NAD+ as a co-substrate Homo sapiens
2.3.1.B41 evolution there are seven evolutionarily conserved mammalian sirtuins (SIRT1-7) distributed to different compartments of the cell. They possess different deacylation activities to post-translationally modulate functions of their targets influencing major cellular pathways. SIRT6 is associated with chromatin and possesses histone deacetylase as well as mono-ADP-ribosylase activities, for both of which it needs NAD+ as a co-substrate Mus musculus
2.3.1.B41 malfunction SIRT6 depletion in cardiac as well as skeletal muscle cells promotes myostatin (Mstn) expression. Upregulation of other factors implicated in muscle atrophy, such as angiotensin-II, activin and Acvr2b, in SIRT6 depleted cells is observed. Effect of SIRT6 deficiency on cardiac expression of muscle-atrophy related genes. Phenotype, detailed overview Homo sapiens
2.3.1.B41 malfunction SIRT6 depletion in cardiac as well as skeletal muscle cells promotes myostatin (Mstn) expression. Upregulation of other factors implicated in muscle atrophy, such as angiotensin-II, activin and Acvr2b, in SIRT6 depleted cells is observed. SIRT6-KO mice show degenerated skeletal muscle phenotype with significant fibrosis, an effect consistent with increased levels of Mstn. SIRT6 overexpression downregulates the cytokine (TNFalpha-IFNgamma)-induced Mstn expression in C2C12 cells, and promotes myogenesis. SIRT6 overexpression mitigates atrophic effect of tumor-induced cytokines in C2C12 cells. Effect of SIRT6 deficiency on cardiac expression of muscle-atrophy related genes. Phenotype, detailed overview Mus musculus
2.3.1.B41 metabolism myostatin (Mstn) and SIRT6 expression exhibit reciprocal relationship, overview Homo sapiens
2.3.1.B41 metabolism myostatin (Mstn) and SIRT6 expression exhibit reciprocal relationship, overview Mus musculus
2.3.1.B41 physiological function the NAD+-dependent lysine deacylases, called sirtuins, are implicated in regulation of wide variety of biological functions ranging from cellular growth, stress-resistance, metabolism, genome stability to aging. Histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy. SIRT6 controls myostatin (Mstn) expression by attenuating NF-kappaB binding to the Mstn promoter. Role for SIRT6 in maintaining muscle mass by controlling expression of atrophic factors like Mstn and activin Homo sapiens
2.3.1.B41 physiological function the NAD+-dependent lysine deacylases, called sirtuins, are implicated in regulation of wide variety of biological functions ranging from cellular growth, stress-resistance, metabolism, genome stability to aging. Histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy. SIRT6 controls myostatin (Mstn) expression by attenuating NF-kappaB binding to the Mstn promoter. Role for SIRT6 in maintaining muscle mass by controlling expression of atrophic factors like Mstn and activin Mus musculus