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Literature summary extracted from

  • Freund, I.; Buhl, D.K.; Boutin, S.; Kotter, A.; Pichot, F.; Marchand, V.; Vierbuchen, T.; Heine, H.; Motorin, Y.; Helm, M.; Dalpke, A.H.; Eigenbrod, T.
    2-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms (2019), RNA, 25, 869-880 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.34 Escherichia coli
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2.1.1.34 Escherichia coli BW25113
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2.1.1.34 Homo sapiens Q13395
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2.1.1.34 Saccharomyces cerevisiae
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Synonyms

EC Number Synonyms Comment Organism
2.1.1.34 TARBP1
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 Homo sapiens
2.1.1.34 TrmH
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 Escherichia coli
2.1.1.34 TrmH
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 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
2.1.1.34 physiological function mutation of TrmH results in loss of Gm18 within tRNA. Lack of 2'-O-methyltransferase TrmH enhances immune stimulatory properties by whole cellular RNA. When using live Escherichia coli bacteria, lack of TrmH does not affect overall immune stimulation although a defined TLR8/RNA-dependent gene expression signature is found upon Escherichia coli infection Escherichia coli
2.1.1.34 physiological function mutation of TrmH results in loss of Gm18 within tRNA. Lack of Gm18 across results in increased immunostimulation of peripheral blood mononuclear cells when activated by tRNA preparations. Lack of Gm18 in yeasts and human cells does not affect immunostimulation by whole RNA preparations Saccharomyces cerevisiae
2.1.1.34 physiological function mutation of TARBP1 results in loss of Gm18 within tRNA. Lack of Gm18 across results in increased immunostimulation of peripheral blood mononuclear cells when activated by tRNA preparations.Lack of Gm18 in yeasts and human cells does not affect immunostimulation by whole RNA preparations Homo sapiens