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Literature summary extracted from
- dUTPase the frequently overlooked enzyme encoded by many retroviruses (2015), Retrovirology, 12, 70 .
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.6.1.23 | D48E/N57S | active site mutant | bovine immunodeficiency virus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.23 | dUTP + H2O | Saccharomyces cerevisiae | - |
dUMP + diphosphate | - |
? |  |
| 3.6.1.23 | dUTP + H2O | Caenorhabditis elegans | - |
dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | Mycobacterium tuberculosis | - |
dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | Plasmodium falciparum | - |
dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | Human gammaherpesvirus 4 | - |
dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | Mason-Pfizer monkey virus | - |
dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | mouse mammary tumor virus | - |
dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | equine infectious anemia virus | - |
dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | feline immunodeficiency virus | - |
dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | Human gammaherpesvirus 8 | - |
dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | Human endogenous retrovirus K | - |
dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | Homo sapiens | - |
dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | bovine immunodeficiency virus | - |
dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | Escherichia coli | - |
dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | Murid gammaherpesvirus 4 | - |
dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | Jembrana disease virus | - |
dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | Caprine arthritis encephalitis virus | - |
dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | Visna-maedi virus | - |
dUMP + diphosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.6.1.23 | bovine immunodeficiency virus | - |
- |
- |
| 3.6.1.23 | Caenorhabditis elegans | - |
- |
- |
| 3.6.1.23 | Caprine arthritis encephalitis virus | - |
- |
- |
| 3.6.1.23 | equine infectious anemia virus | - |
- |
- |
| 3.6.1.23 | Escherichia coli | P06968 | - |
- |
| 3.6.1.23 | feline immunodeficiency virus | - |
- |
- |
| 3.6.1.23 | Homo sapiens | P33316 | - |
- |
| 3.6.1.23 | Human endogenous retrovirus K | - |
- |
- |
| 3.6.1.23 | Human gammaherpesvirus 4 | - |
- |
- |
| 3.6.1.23 | Human gammaherpesvirus 8 | - |
- |
- |
| 3.6.1.23 | Jembrana disease virus | - |
- |
- |
| 3.6.1.23 | Mason-Pfizer monkey virus | - |
- |
- |
| 3.6.1.23 | mouse mammary tumor virus | - |
- |
- |
| 3.6.1.23 | Murid gammaherpesvirus 4 | - |
- |
- |
| 3.6.1.23 | Mycobacterium tuberculosis | - |
- |
- |
| 3.6.1.23 | Plasmodium falciparum | - |
- |
- |
| 3.6.1.23 | Saccharomyces cerevisiae | - |
- |
- |
| 3.6.1.23 | Visna-maedi virus | - |
of sheep | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.23 | dUTP + H2O | - |
Saccharomyces cerevisiae | dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | - |
Caenorhabditis elegans | dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | - |
Mycobacterium tuberculosis | dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | - |
Plasmodium falciparum | dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | - |
Human gammaherpesvirus 4 | dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | - |
Mason-Pfizer monkey virus | dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | - |
mouse mammary tumor virus | dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | - |
equine infectious anemia virus | dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | - |
feline immunodeficiency virus | dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | - |
Human gammaherpesvirus 8 | dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | - |
Human endogenous retrovirus K | dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | - |
Homo sapiens | dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | - |
bovine immunodeficiency virus | dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | - |
Escherichia coli | dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | - |
Murid gammaherpesvirus 4 | dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | - |
Jembrana disease virus | dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | - |
Caprine arthritis encephalitis virus | dUMP + diphosphate | - |
? | |
| 3.6.1.23 | dUTP + H2O | - |
Visna-maedi virus | dUMP + diphosphate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.6.1.23 | homotrimer | - |
Homo sapiens |
| 3.6.1.23 | homotrimer | - |
Escherichia coli |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Saccharomyces cerevisiae |
| 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Caenorhabditis elegans |
| 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Mycobacterium tuberculosis |
| 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Plasmodium falciparum |
| 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Human gammaherpesvirus 4 |
| 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Mason-Pfizer monkey virus |
| 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
mouse mammary tumor virus |
| 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
equine infectious anemia virus |
| 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
feline immunodeficiency virus |
| 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Human gammaherpesvirus 8 |
| 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Human endogenous retrovirus K |
| 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Homo sapiens |
| 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
bovine immunodeficiency virus |
| 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Escherichia coli |
| 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Murid gammaherpesvirus 4 |
| 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Jembrana disease virus |
| 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Caprine arthritis encephalitis virus |
| 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | - |
Visna-maedi virus |
| 3.6.1.23 | dUTPase | - |
Saccharomyces cerevisiae |
| 3.6.1.23 | dUTPase | - |
Caenorhabditis elegans |
| 3.6.1.23 | dUTPase | - |
Mycobacterium tuberculosis |
| 3.6.1.23 | dUTPase | - |
Plasmodium falciparum |
| 3.6.1.23 | dUTPase | - |
Human gammaherpesvirus 4 |
| 3.6.1.23 | dUTPase | - |
Mason-Pfizer monkey virus |
| 3.6.1.23 | dUTPase | - |
mouse mammary tumor virus |
| 3.6.1.23 | dUTPase | - |
equine infectious anemia virus |
| 3.6.1.23 | dUTPase | - |
feline immunodeficiency virus |
| 3.6.1.23 | dUTPase | - |
Human gammaherpesvirus 8 |
| 3.6.1.23 | dUTPase | - |
Human endogenous retrovirus K |
| 3.6.1.23 | dUTPase | - |
Homo sapiens |
| 3.6.1.23 | dUTPase | - |
bovine immunodeficiency virus |
| 3.6.1.23 | dUTPase | - |
Escherichia coli |
| 3.6.1.23 | dUTPase | - |
Murid gammaherpesvirus 4 |
| 3.6.1.23 | dUTPase | - |
Jembrana disease virus |
| 3.6.1.23 | dUTPase | - |
Caprine arthritis encephalitis virus |
| 3.6.1.23 | dUTPase | - |
Visna-maedi virus |
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