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Literature summary extracted from

  • Ziv, C.; Malitsky, S.; Othman, A.; Ben-Dor, S.; Wei, Y.; Zheng, S.; Aharoni, A.; Hornemann, T.; Vardi, A.
    Viral serine palmitoyltransferase induces metabolic switch in sphingolipid biosynthesis and is required for infection of a marine alga (2016), Proc. Natl. Acad. Sci. USA, 113, E1907-E1916 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.50 myriocin
-
 Emiliania huxleyi
2.3.1.50 myriocin
-
 Emiliania huxleyi virus sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.50 palmitoyl-CoA + L-serine Emiliania huxleyi virus sp.
-
 CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine Emiliania huxleyi virus sp. 201
-
 CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 pentadecanoyl-CoA + L-serine Emiliania huxleyi
-
 ?
-
 ?
2.3.1.50 pentadecanoyl-CoA + L-serine Emiliania huxleyi CCMP374
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.50 Emiliania huxleyi
-
-
-
2.3.1.50 Emiliania huxleyi CCMP374
-
-
-
2.3.1.50 Emiliania huxleyi virus sp.
-
-
-
2.3.1.50 Emiliania huxleyi virus sp. 201
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.50 heptadecanoyl-CoA + L-serine
-
 Emiliania huxleyi ?
-
 ?
2.3.1.50 heptadecanoyl-CoA + L-serine less than 50% activity compared to palmitoyl-CoA Emiliania huxleyi virus sp. ?
-
 ?
2.3.1.50 heptadecanoyl-CoA + L-serine less than 50% activity compared to palmitoyl-CoA Emiliania huxleyi virus sp. 201 ?
-
 ?
2.3.1.50 heptadecanoyl-CoA + L-serine
-
 Emiliania huxleyi CCMP374 ?
-
 ?
2.3.1.50 myristoyl-CoA + L-serine
-
 Emiliania huxleyi ?
-
 ?
2.3.1.50 myristoyl-CoA + L-serine less than 50% activity compared to palmitoyl-CoA Emiliania huxleyi virus sp. ?
-
 ?
2.3.1.50 myristoyl-CoA + L-serine less than 50% activity compared to palmitoyl-CoA Emiliania huxleyi virus sp. 201 ?
-
 ?
2.3.1.50 myristoyl-CoA + L-serine
-
 Emiliania huxleyi CCMP374 ?
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine
-
 Emiliania huxleyi CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine
-
 Emiliania huxleyi virus sp. CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine 100% activity Emiliania huxleyi virus sp. CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine
-
 Emiliania huxleyi virus sp. 201 CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine 100% activity Emiliania huxleyi virus sp. 201 CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine
-
 Emiliania huxleyi CCMP374 CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 pentadecanoyl-CoA + L-serine
-
 Emiliania huxleyi ?
-
 ?
2.3.1.50 pentadecanoyl-CoA + L-serine less than 50% activity compared to palmitoyl-CoA Emiliania huxleyi virus sp. ?
-
 ?
2.3.1.50 pentadecanoyl-CoA + L-serine less than 50% activity compared to palmitoyl-CoA Emiliania huxleyi virus sp. 201 ?
-
 ?
2.3.1.50 pentadecanoyl-CoA + L-serine
-
 Emiliania huxleyi CCMP374 ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.50 ? x * 100000, SDS-PAGE Emiliania huxleyi

Synonyms

EC Number Synonyms Comment Organism
2.3.1.50 serine palmitoyltransferase
-
 Emiliania huxleyi
2.3.1.50 serine palmitoyltransferase
-
 Emiliania huxleyi virus sp.
2.3.1.50 SPT
-
 Emiliania huxleyi
2.3.1.50 SPT
-
 Emiliania huxleyi virus sp.

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.50 pyridoxal 5'-phosphate
-
 Emiliania huxleyi
2.3.1.50 pyridoxal 5'-phosphate
-
 Emiliania huxleyi virus sp.

Expression

EC Number Organism Comment Expression
2.3.1.50 Emiliania huxleyi virus sp. the enzyme is highly expressed at early stages of infection of the host Emiliania huxleyi up