Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Zufferey, R.; Pirani, K.; Cheung-See-Kit, M.; Lee, S.; Williams, T.; Chen, D.; Hossain, M.
    The Trypanosoma brucei dihydroxyacetonephosphate acyltransferase TbDAT is dispensable for normal growth but important for synthesis of ether glycerophospholipids (2017), PLoS ONE, 12, e0181432 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.42 expressed in Saccharomyces cerevisiae cells Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.42 glycosome
-
 Trypanosoma brucei 20015
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.42 acyl-CoA + glycerone phosphate Trypanosoma brucei
-
 CoA + acylglycerone phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.42 Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.42 acyl-CoA + glycerone phosphate
-
 Trypanosoma brucei CoA + acylglycerone phosphate
-
 ?
2.3.1.42 arachidonoyl-CoA + glycerone phosphate less than 10% activity compared to palmitoyl-CoA Trypanosoma brucei CoA + arachidonoylglycerone phosphate
-
 ?
2.3.1.42 lauroyl-CoA + glycerone phosphate less than 10% activity compared to palmitoyl-CoA Trypanosoma brucei CoA + lauroylglycerone phosphate
-
 ?
2.3.1.42 linoleoyl-CoA + glycerone phosphate about 25% activity compared to palmitoyl-CoA Trypanosoma brucei CoA + linoleoylglycerone phosphate
-
 ?
2.3.1.42 myristoyl-CoA + glycerone phosphate about 60% activity compared to palmitoyl-CoA Trypanosoma brucei CoA + myristoylglycerone phosphate
-
 ?
2.3.1.42 oleoyl-CoA + glycerone phosphate about 35% activity compared to palmitoyl-CoA Trypanosoma brucei CoA + oleoylglycerone phosphate
-
 ?
2.3.1.42 palmitoleoyl-CoA + glycerone phosphate about 60% activity compared to palmitoyl-CoA Trypanosoma brucei CoA + palmitoleoylglycerone phosphate
-
 ?
2.3.1.42 palmitoyl-CoA + glycerone phosphate 100% activity. Palmitoyl-CoA is the preferred acyl-CoA donor Trypanosoma brucei CoA + palmitoylglycerone phosphate
-
 ?
2.3.1.42 stearoyl-CoA + glycerone phosphate about 20% activity compared to palmitoyl-CoA Trypanosoma brucei CoA + stearoylglycerone phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.42 ? x * 137000, calculated from amino acid sequence Trypanosoma brucei

Synonyms

EC Number Synonyms Comment Organism
2.3.1.42 DAT
-
 Trypanosoma brucei
2.3.1.42 DHAP acyltransferase
-
 Trypanosoma brucei
2.3.1.42 DHAPAT
-
 Trypanosoma brucei
2.3.1.42 dihydroxyacetonephosphate acyltransferase
-
 Trypanosoma brucei

General Information

EC Number General Information Comment Organism
2.3.1.42 metabolism in Trypanosoma brucei procyclic forms the enzyme is the physiologically relevant initial acyltransferase producing ether lipid precursors Trypanosoma brucei
2.3.1.42 physiological function the enzyme is important for survival during stationary phase and synthesis of ether lipids. In contrast, the enzyme is dispensable for normal growth Trypanosoma brucei