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Literature summary extracted from
- Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy (2018), PLoS Genet., 14, e1007561 .
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.1.1.1 | Caenorhabditis elegans | P34254 | - |
- |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.1.1.1 | ANMT-1 | - |
Caenorhabditis elegans |
| 2.1.1.1 | B0303.2 | - |
Caenorhabditis elegans |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 2.1.1.1 | physiological function | ortholog ANMT-1 competes with the methyltransferase LCMT-1 for methyl groups from S-adenosyl methionine. Thereby, it regulates the catalytic capacities of LCMT-1, targeting NPRL-2, a regulator of autophagy. During aging, high neuronal ANMT-1 activity induce autophagy via NPRL-2. In younger animals, ANMT-1 activity disturbs neuronal homeostasis and dopamine signaling, causing abnormal behavior | Caenorhabditis elegans |
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Release 2023.1 (January 2023)
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