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Literature summary extracted from

  • Pandith, S.A.; Ramazan, S.; Khan, M.I.; Reshi, Z.A.; Shah, M.A.
    Chalcone synthases (CHSs) the symbolic type III polyketide synthases (2019), Planta, 251, 15 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.74 cytoplasm
-
 Rheum australe 5737
-
2.3.1.74 nucleus
-
 Rheum australe 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.74 3 malonyl-CoA + 4-coumaroyl-CoA Rheum australe 100% activity 4 CoA + naringenin chalcone + 3 CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.74 Rheum australe A0A096X8J8
-
-
2.3.1.74 Rheum australe A0A0A0P7Q3
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.74 (2RS)-methylmalonyl-CoA + n-hexanoyl-CoA
-
 Rheum australe triketide lactone + 6-ethyl-4-hydroxy-3,5-dimethyl-2-pyrone
-
 ?
2.3.1.74 3 malonyl-CoA + 4-coumaroyl-CoA 100% activity Rheum australe 4 CoA + naringenin chalcone + 3 CO2
-
 ?
2.3.1.74 4-coumaroyl-CoA + (2RS)-methylmalonyl-CoA
-
 Rheum australe 1-(4-hydroxyphenyl)pent-1-en-3-one
-
 ?
2.3.1.74 cinnamoyl diketide-NAC + (2RS)-methylmalonyl-CoA
-
 Rheum australe methylated triketide styrylpyrone + ?
-
 ?
2.3.1.74 malonyl-CoA + 4-fluorocinnamoyl-CoA
-
 Rheum australe fluorinated chalcone + alpha-pyrone + 2 CoA
-
 ?
2.3.1.74 malonyl-CoA + acetyl-CoA isoform CHS1 exhibits 21.15% activity compared to 4-coumaryl-CoA Rheum australe ?
-
 ?
2.3.1.74 malonyl-CoA + acetyl-CoA isoform CHS2 exhibits 138.11% activity compared to 4-coumaryl-CoA Rheum australe ?
-
 ?
2.3.1.74 malonyl-CoA + benzoyl-CoA
-
 Rheum australe bis-noryangonin + 4-coumaroyl triacetic acid lactone + CoA + CO2
-
 ?
2.3.1.74 malonyl-CoA + butyryl-CoA isoform CHS1 exhibits 18.85% activity compared to 4-coumaryl-CoA Rheum australe ?
-
 ?
2.3.1.74 malonyl-CoA + butyryl-CoA isoform CHS2 exhibits 45.38% activity compared to 4-coumaryl-CoA Rheum australe ?
-
 ?
2.3.1.74 malonyl-CoA + hexanoyl-CoA isoform CHS1 exhibits 3.09% activity compared to 4-coumaryl-CoA Rheum australe ?
-
 ?
2.3.1.74 malonyl-CoA + hexanoyl-CoA isoform CHS2 exhibits 2.36% activity compared to 4-coumaryl-CoA Rheum australe ?
-
 ?
2.3.1.74 malonyl-CoA + octanoyl-CoA isoform CHS1 exhibits 22.04% activity compared to 4-coumaryl-CoA Rheum australe ?
-
 ?
2.3.1.74 malonyl-CoA + octanoyl-CoA isoform CHS2 exhibits 72.39% activity compared to 4-coumaryl-CoA Rheum australe ?
-
 ?
2.3.1.74 methylmalonyl-CoA + benzoyl-CoA
-
 Rheum australe triketide alpha-pyrone + tetraketide alpha-pyrone
-
 ?
2.3.1.74 n-hexanoyl-CoA + butyryl-CoA
-
 Rheum australe phlorobutyrophenone + phlorocaprophenone
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.74 homodimer 2 * about 43230, calculated from amino acid sequence Rheum australe

Synonyms

EC Number Synonyms Comment Organism
2.3.1.74 Chs1 isoform Rheum australe
2.3.1.74 Chs2 isoform Rheum australe

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.3.1.74 Rheum australe calculated from amino acid sequence
-
 6

General Information

EC Number General Information Comment Organism
2.3.1.74 metabolism the enzyme catalyzes the initial step of the phenylpropanoid pathway Rheum australe

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.3.1.74 10
-
 hexanoyl-CoA isoform CHS1, pH and temperature not specified in the publication Rheum australe
2.3.1.74 30
-
 octanoyl-CoA isoform CHS1, pH and temperature not specified in the publication Rheum australe
2.3.1.74 50
-
 acetyl-CoA isoform CHS1, pH and temperature not specified in the publication Rheum australe
2.3.1.74 50
-
 butyryl-CoA isoform CHS1, pH and temperature not specified in the publication Rheum australe
2.3.1.74 170
-
 4-coumaroyl-CoA isoform CHS2, pH and temperature not specified in the publication Rheum australe
2.3.1.74 300
-
 hexanoyl-CoA isoform CHS2, pH and temperature not specified in the publication Rheum australe
2.3.1.74 580
-
 octanoyl-CoA isoform CHS2, pH and temperature not specified in the publication Rheum australe
2.3.1.74 787
-
 4-coumaroyl-CoA isoform CHS1, pH and temperature not specified in the publication Rheum australe
2.3.1.74 990
-
 butyryl-CoA isoform CHS2, pH and temperature not specified in the publication Rheum australe
2.3.1.74 1240
-
 acetyl-CoA isoform CHS2, pH and temperature not specified in the publication Rheum australe