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Literature summary extracted from

  • Keereetaweep, J.; Liu, H.; Zhai, Z.; Shanklin, J.
    Biotin attachment domain-containing proteins irreversibly inhibit acetyl CoA carboxylase (2018), Plant Physiol., 177, 208-215 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.3.15 additional information incorporation of biotin attachment domain-containing proteins (inactive analogs of biotin carboxyl transfer proteins that lack biotin) into the enzyme down-regulates its activity by displacing active (biotin-containing) biotin carboxyltransferase protein subunits Arabidopsis thaliana
2.1.3.15 oleic acid irreversible enzyme inhibition Arabidopsis thaliana
2.1.3.15 Tween 80 reversible enzyme inhibition at 10 mM Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.3.15 [biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA Arabidopsis thaliana
-
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.3.15 Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.3.15 [biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
-
Arabidopsis thaliana [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
-
?

Synonyms

EC Number Synonyms Comment Organism
2.1.3.15 ACCase
-
Arabidopsis thaliana
2.1.3.15 Acetyl CoA carboxylase
-
Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.3.15 biotin dependent on Arabidopsis thaliana