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Literature summary extracted from

  • Zhang, H.; Zhao, Z.; Wang, T.; Wang, Y.; Cui, X.; Zhang, H.; Fang, Z.Z.
    Inhibition of UDP-glucuronosyltransferase (UGT) isoforms by arctiin and arctigenin (2016), Phytother. Res., 30, 1189-1196 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.17 arctigenin about 210% activity of isoform UGT1A8 at 0.1 mM arctigenin Homo sapiens
2.4.1.17 arctiin about 225% activity of isoform UGT1A8 at 0.1 mM arctiin Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 arctigenin about 20% inhibition at 0.1 mM; about 35% inhibition at 0.1 mM; about 50% inhibition at 0.1 mM; about 50% inhibition at 0.1 mM; about 65% inhibition at 0.1 mM; about 80% inhibition at 0.1 mM; about 82% inhibition at 0.1 mM; about 90% inhibition at 0.1 mM; noncompetitive inhibition toward isoform UGT2B15 with more than 80% inhibition at 0.1 mM Homo sapiens
2.4.1.17 arctiin about 20% inhibition at 0.1 mM; about 35% inhibition at 0.1 mM; about 50% inhibition at 0.1 mM; about 50% inhibition at 0.1 mM; about 65% inhibition at 0.1 mM; about 80% inhibition at 0.1 mM; about 82% inhibition at 0.1 mM; about 85% inhibition at 0.1 mM; competitive inhibition toward isoform UGT2B15 with more than 80% inhibition at 0.1 mM Homo sapiens
2.4.1.17 atractylenolide I inhibitor of isoform UGT2B7 Homo sapiens
2.4.1.17 gomisin J inhibitor of isoform UGT1A9 Homo sapiens
2.4.1.17 schisandrin A inhibitor of isoform UGT1A1; inhibitor of isoform UGT1A3 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mg2+ 5 mM used in assay conditions Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens O60656
-
-
2.4.1.17 Homo sapiens O75795
-
-
2.4.1.17 Homo sapiens P06133
-
-
2.4.1.17 Homo sapiens P16662
-
-
2.4.1.17 Homo sapiens P19224
-
-
2.4.1.17 Homo sapiens P22309
-
-
2.4.1.17 Homo sapiens P35503
-
-
2.4.1.17 Homo sapiens P54855
-
-
2.4.1.17 Homo sapiens Q9HAW7
-
-
2.4.1.17 Homo sapiens Q9HAW9
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 4-methylumbelliferone + UDP-glucuronate
-
 Homo sapiens UDP + 4-methylumbelliferyl beta-D-glucuronide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase
-
 Homo sapiens
2.4.1.17 UGT1A1 isoform Homo sapiens
2.4.1.17 UGT1A3 isoform Homo sapiens
2.4.1.17 UGT1A6 isoform Homo sapiens
2.4.1.17 UGT1A7 isoform Homo sapiens
2.4.1.17 UGT1A8 isoform Homo sapiens
2.4.1.17 UGT1A9 isoform Homo sapiens
2.4.1.17 UGT2B15 isoform Homo sapiens
2.4.1.17 UGT2B17 isoform Homo sapiens
2.4.1.17 UGT2B4 isoform Homo sapiens
2.4.1.17 UGT2B7 isoform Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.17 0.016
-
 arctiin isoform UGT2B15, at pH 7.4 and 37°C Homo sapiens
2.4.1.17 0.0767
-
 arctigenin isoform UGT2B15, at pH 7.4 and 37°C Homo sapiens