Literature summary extracted from

Wang, J.; Wang, X.H.; Liu, X.; Li, J.; Shi, X.P.; Song, Y.L.; Zeng, K.W.; Zhang, L.; Tu, P.F.; Shi, S.P.
Synthesis of unnatural 2-substituted quinolones and 1,3-diketones by a member of type III polyketide synthases from Huperzia serrata (2016), Org. Lett., 18, 3550-3553 .

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.1.212	Huperzia serrata	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.3.1.212	4-coumaroyl-CoA + malonyl-CoA + H2O	the enzyme catalyzes the formation of unnatural 2-substituted quinolones and 1,3-diketones via head-to-head condensation of two completely different substrates. The broad range of substrate tolerance of HsPKS3 facilitates accessing structurally diverse 2-substituted quinolones and 1,3-diketones	Huperzia serrata	2 CoA + 4-hydroxybenzalacetone + 2 CO2	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.3.1.212	HsPKS3	-	Huperzia serrata

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Release 2023.1 (January 2023)