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Literature summary extracted from

  • Hu, J.; Deng, F.; Hu, X.; Zhang, W.; Zeng, X.; Tian, X.
    Histone deacetylase SIRT6 regulates chemosensitivity in liver cancer cells via modulation of FOXO3 activity (2018), Oncol. Rep., 40, 3635-3644 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.B41 gene SIRT6, transient overexpression of FLAG-tagged SIRT6 in HeLa cells, quantitative reverse transcription PCR enzyme expression analysis Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.B41 additional information specific downregulation of histone deacetylase sirtuin 6 (SIRT6), overexpression of SIRT6. In Hep-G2 cells, doxorubicin treatment results in significant increases in SIRT1 and SIRT4 mRNA expression and downregulation of SIRT6 mRNA level by 36 h Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.B41 NAD+ + [protein]-N6-palmitoyl-L-lysine Homo sapiens
-
 nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.B41 Homo sapiens Q8N6T7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.B41 Hep-G2 cell
-
 Homo sapiens
-
2.3.1.B41 hepatoma cell
-
 Homo sapiens
-
2.3.1.B41 Huh-7 cell
-
 Homo sapiens
-
2.3.1.B41 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.B41 NAD+ + [protein]-N6-palmitoyl-L-lysine
-
 Homo sapiens nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.B41 histone deacetylase
-
 Homo sapiens
2.3.1.B41 SIRT6
-
 Homo sapiens
2.3.1.B41 sirtuin 6
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.B41 NAD+
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.3.1.B41 Homo sapiens in Hep-G2 cells, doxorubicin treatment results in significant increases in SIRT1 and SIRT4 mRNA expression and downregulation of SIRT6 mRNA level by 36 h down

General Information

EC Number General Information Comment Organism
2.3.1.B41 malfunction downregulation of SIRT6 enables forkhead box O3 (FOXO3) upregulation, translocation into the nucleus, and increased expression of its target genes p27 and Bim, which further induce apoptosis. Overexpression of SIRT6, but not enzyme-inactivated mutants, prevents FOXO3 translocation into the nucleus and doxorubicin-induced cell death Homo sapiens
2.3.1.B41 physiological function histone deacetylase SIRT6, one of the SIRT proteins, plays critical roles in controlling metabolism, genomic stability, inflammation, aging and cancer progression. SIRT6 regulates chemosensitivity in liver cancer cells via modulation of FOXO3 activity. SIRT6 interacts with FOXO3 and this interaction increases FOXO3 ubiquitination and decreases its stability. The effect of SIRT6 in preventing doxorubicin-induced cell death requires FOXO3. Overexpression of SIRT6 could not prevent doxorubicin-induced cell death in FOXO3 knockdown cells. SIRT6 plays a central role in determining doxorubicin-induced cell death via modulation of FOXO3 activity Homo sapiens