Literature summary extracted from

Jacob, Y.; Feng, S.; LeBlanc, C.A.; Bernatavichute, Y.V.; Stroud, H.; Cokus, S.; Johnson, L.M.; Pellegrini, M.; Jacobsen, S.E.;Michaels, S.D.
ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing (2009), Nat. Struct. Mol. Biol., 16, 763-768 .

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.1.1.369	S-adenosyl-L-methionine + [histone H3]-L-lysine27	Arabidopsis thaliana	-	S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine27	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.369	Arabidopsis thaliana	Q8VZJ1	-	-
2.1.1.369	Arabidopsis thaliana	Q9FNE9	isoform Atxr6	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.369	additional information	isoforms Atxr5 and Atxr6 specifically monomethylate histone H3K27	Arabidopsis thaliana	?	-	-
2.1.1.369	S-adenosyl-L-methionine + [histone H3]-L-lysine27	-	Arabidopsis thaliana	S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine27	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.1.1.369	ATXR5	-	Arabidopsis thaliana
2.1.1.369	Atxr6	-	Arabidopsis thaliana
2.1.1.369	trithorax-related protein 5	-	Arabidopsis thaliana
2.1.1.369	trithorax-related protein 6	-	Arabidopsis thaliana

General Information

EC Number	General Information	Comment	Organism
2.1.1.369	physiological function	isoforms ATXR5 and ATXR6 exhibit histone H3K27 monomethyltransferase activity and double mutants have reduced H3K27me1 levels in vivo and show partial heterochromatin decondensation. Mutations in Atxr5 and Atxr6 also lead to transcriptional activation of repressed heterochromatic elements. H3K9me2 and DNA methylation are unaffected in the double mutant	Arabidopsis thaliana

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)