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Literature summary extracted from

  • Xie, Y.; Miranda, S.R.; Hoskins, J.M.; Hawke, R.L.
    Role of UDP-glucuronosyltransferase 1A1 in the metabolism and pharmacokinetics of silymarin flavonolignans in patients with HCV and NAFLD (2017), Molecules, 22, 142 .
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 0.0087
-
 silybin B at pH 7.4 and 37°C Homo sapiens
2.4.1.17 0.009
-
 silydianin at pH 7.4 and 37°C Homo sapiens
2.4.1.17 0.023
-
 silybin A at pH 7.4 and 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens P22309
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 7-hydroxy-4-trifluoromethylcoumarin + UDP-glucuronate
-
 Homo sapiens UDP + 7-hydroxy-4-trifluoromethylcoumarin beta-D-glucuronide
-
 ?
2.4.1.17 silybin A + UDP-glucuronate
-
 Homo sapiens UDP + ?
-
 ?
2.4.1.17 silybin B + UDP-glucuronate
-
 Homo sapiens UDP + ?
-
 ?
2.4.1.17 silydianin + UDP-glucuronate
-
 Homo sapiens UDP + silydianin beta-D-glucuronide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase
-
 Homo sapiens
2.4.1.17 UGT1A1 isoform Homo sapiens