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Literature summary extracted from

  • Han, L.; Jia, L.; Wu, F.; Huang, C.
    Sirtuin6 (SIRT6) promotes the EMT of hepatocellular carcinoma by stimulating autophagic degradation of E-cadherin (2019), Mol. Cancer Res., 17, 2267-2280 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.B41 gene SIRT&, quantitative RT-PCR enzyme expression analysis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.B41 additional information Homo sapiens SIRT6 deacetylates Beclin-1 in HCC cells ?
-
-
2.3.1.B41 NAD+ + [protein]-N6-palmitoyl-L-lysine Homo sapiens
-
 nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.B41 Homo sapiens
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.B41 hepatocyte
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 Homo sapiens
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2.3.1.B41 hepatoma cell increased SIRT6 expression in HCC, SIRT6 expression pattern and its association with HCC metastasis, overview Homo sapiens
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2.3.1.B41 HL-7702 cell
-
 Homo sapiens
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2.3.1.B41 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.B41 additional information SIRT6 deacetylates Beclin-1 in HCC cells Homo sapiens ?
-
-
2.3.1.B41 NAD+ + [protein]-N6-palmitoyl-L-lysine
-
 Homo sapiens nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.B41 SIRT6
-
 Homo sapiens
2.3.1.B41 Sirtuin6
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.B41 NAD+
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.B41 evolution sirtuin6 belongs to the Sirtuin family Homo sapiens
2.3.1.B41 physiological function sirtuin family members function as NAD+-dependent deacetylases that are essential for tumor metastasis and epithelial-mesenchymal transition (EMT). EMT is a pivotal mechanism involved in tumor metastasis, which is the leading cause of poor prognosis for hepatocellular carcinoma (HCC). Increased sirtuin6 expression in hepatocellular carcinoma is associated with the poor prognosis. Sirtuin6 (SIRT6) promotes the EMT of hepatocellular carcinoma by stimulating autophagic degradation of E-cadherin via the lysosomal pathway. SIRT6 deacetylates Beclin-1 in HCC cells and this event leads to the promotion of the autophagic degradation of E-cadherin. E-cadherin degradation, invasion, and migration induced by SIRT6 overexpression can be rescued by dual mutation of Beclin-1 (inhibition of acetylation), CQ (autophagy inhibitor), and knockdown of Atg7. In addition, SIRT6 promotes N-cadherin and Vimentin expression via deacetylating FOXO3a in HCC. An increased vimentin and N-cadherin expression can be observed after SIRT6 is upregulated in Hep3B and LO2 cells. In MHCC-97H cells, downregulated SIRT6 causes opposite results Homo sapiens