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Literature summary extracted from

  • Gwin, C.M.; Prakash, N.; Christian Belisario, J.; Haider, L.; Rosen, M.L.; Martinez, L.R.; Rigel, N.W.
    The apolipoprotein N-acyl transferase Lnt is dispensable for growth in Acinetobacter species (2018), Microbiology, 164, 1547-1556 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.269 additional information generation of loss-of-function mutants of Lnt, i.e. lnt153::T26, phenotypes, overview Acinetobacter baumannii
2.3.1.269 additional information generation of loss-of-function mutants of Lnt, phenotypes, overview Acinetobacter baylyi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.269 a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine Acinetobacter baumannii
-
 a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?
2.3.1.269 a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine Acinetobacter baylyi
-
 a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?
2.3.1.269 a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine Acinetobacter baylyi BD413
-
 a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?
2.3.1.269 a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine Acinetobacter baylyi ATCC 33305
-
 a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?
2.3.1.269 a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine Acinetobacter baumannii AB5075-UW
-
 a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.269 Acinetobacter baumannii A0A090B6R9
-
-
2.3.1.269 Acinetobacter baumannii AB5075-UW A0A090B6R9
-
-
2.3.1.269 Acinetobacter baylyi Q6FF00
-
-
2.3.1.269 Acinetobacter baylyi ATCC 33305 Q6FF00
-
-
2.3.1.269 Acinetobacter baylyi BD413 Q6FF00
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.269 a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 Acinetobacter baumannii a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?
2.3.1.269 a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 Acinetobacter baylyi a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?
2.3.1.269 a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 Acinetobacter baylyi BD413 a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?
2.3.1.269 a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 Acinetobacter baylyi ATCC 33305 a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?
2.3.1.269 a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 Acinetobacter baumannii AB5075-UW a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.269 ALP N-acyltransferase UniProt Acinetobacter baumannii
2.3.1.269 lnt
-
 Acinetobacter baumannii
2.3.1.269 lnt
-
 Acinetobacter baylyi

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.269 37
-
 assay at Acinetobacter baumannii
2.3.1.269 37
-
 assay at Acinetobacter baylyi

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.269 7.2
-
 assay at Acinetobacter baumannii
2.3.1.269 7.2
-
 assay at Acinetobacter baylyi

General Information

EC Number General Information Comment Organism
2.3.1.269 malfunction Acinetobacter species can tolerate a complete loss-of-function mutation in gene lnt. Absence of a fully functional Lnt impairs modification of lipoproteins, increases outer membrane permeability and susceptibility to antibiotics, and alters normal cellular morphology. In addition, loss of lnt triggers a global transcriptional response to this added cellular stress. Without Lnt, the bacterial cell envelope becomes more permeable and modification of outer membrane lipoproteins is impaired. Cells of the lnt mutant have structural defects. The genome expression profile of Acinetobacter baylyi changes in response to lnt mutation. Phenotypes, overview Acinetobacter baylyi
2.3.1.269 malfunction Acinetobacter species can tolerate a complete loss-of-function mutation in gene lnt. Absence of a fully functional Lnt impairs modification of lipoproteins, increases outer membrane permeability and susceptibility to antibiotics, and alters normal cellular morphology. In addition, loss of lnt triggers a global transcriptional response to this added cellular stress. Without Lnt, the bacterial cell envelope becomes more permeable and modification of outer membrane lipoproteins is impaired. Phenotypes, overview Acinetobacter baumannii
2.3.1.269 metabolism genome expression profile of Acinetobacter baylyi changes in response to gene lnt mutation, overview Acinetobacter baylyi
2.3.1.269 physiological function proper acylation of outer membrane lipoprotein BamD requires enzyme Lnt in Acinetobacter baylyi. Lnt is required for full maturation of outer membrane lipoprotein BamD Acinetobacter baylyi