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Literature summary extracted from

  • Jalal, N.; Tian, X.L.; Dong, G.; Upham, J.; Chen, C.; Parcells, M.; Li, Y.H.
    Identification and characterization of SMU.244 encoding a putative undecaprenyl pyrophosphate phosphatase protein required for cell wall biosynthesis and bacitracin resistance in Streptococcus mutans (2015), Microbiology, 161, 1857-1870 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.27 expressed in Escherichia coli BL21(DE3)pLyS cells Streptococcus mutans

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.27 EDTA complete inhibition at 5 mM Streptococcus mutans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.1.27 membrane
-
 Streptococcus mutans 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.27 Mg2+ 10 mM used in assay conditions Streptococcus mutans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.27 undecaprenyl diphosphate + H2O Streptococcus mutans
-
 undecaprenyl phosphate + phosphate
-
 ?
3.6.1.27 undecaprenyl diphosphate + H2O Streptococcus mutans WT UA159
-
 undecaprenyl phosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.27 Streptococcus mutans
-
-
-
3.6.1.27 Streptococcus mutans WT UA159
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.27 Ni-charged resin column chromatography Streptococcus mutans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.27 farnesyl diphosphate + H2O
-
 Streptococcus mutans farnesyl phosphate + phosphate
-
 ?
3.6.1.27 farnesyl diphosphate + H2O
-
 Streptococcus mutans WT UA159 farnesyl phosphate + phosphate
-
 ?
3.6.1.27 undecaprenyl diphosphate + H2O
-
 Streptococcus mutans undecaprenyl phosphate + phosphate
-
 ?
3.6.1.27 undecaprenyl diphosphate + H2O
-
 Streptococcus mutans WT UA159 undecaprenyl phosphate + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.6.1.27 ? x * 31232, calculated from amino acid sequence Streptococcus mutans

Synonyms

EC Number Synonyms Comment Organism
3.6.1.27 SMU.244 locus name Streptococcus mutans
3.6.1.27 undecaprenyl pyrophosphate phosphatase
-
 Streptococcus mutans
3.6.1.27 UppP
-
 Streptococcus mutans

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.6.1.27 Streptococcus mutans calculated from amino acid sequence
-
 10

Expression

EC Number Organism Comment Expression
3.6.1.27 Streptococcus mutans enzyme expression is induced by a sub-MIC of bacitracin up

General Information

EC Number General Information Comment Organism
3.6.1.27 malfunction enzyme deletion results in a mutant with reduced biofilm formation that is highly sensitive to bacitracin, but confers more resistance to lactococcin G Streptococcus mutans
3.6.1.27 physiological function the enzyme plays important roles in cell wall biosynthesis and bacitracin resistance Streptococcus mutans