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Literature summary extracted from

  • Zhang, Y.; Zhou, X.; Wang, X.; Wang, L.; Xia, M.; Luo, J.; Shen, Y.; Wang, M.
    Improving phytosterol biotransformation at low nitrogen levels by enhancing the methylcitrate cycle with transcriptional regulators PrpR and GlnR of Mycobacterium neoaurum (2020), Microb. Cell Fact., 19, 13 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.3.3.5 drug development androstenedione is an important steroid medicine intermediate that is obtained via the degradation of phytosterols by mycobacteria. The production process of androstenedione is mainly the degradation of the phytosterol aliphatic side chain, which is accompanied by the production of propionyl CoA. Excessive accumulation of intracellular propionyl-CoA produces a toxic effect in mycobacteria, which restricts the improvement of production efficiency. Biotransformation at low nitrogen levels can be improved by enhancing the methylcitrate cycle with transcriptional regulators PrpR and GlnR of Mycobacterium neoaurum Mycolicibacterium neoaurum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.3.5 propanoyl-CoA + H2O + oxaloacetate Mycolicibacterium neoaurum the enzyme is involved in the 2-methylcitrate cycle pathway which plays a significant role in the detoxification of propionyl-CoA in bacteria (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.5 Mycolicibacterium neoaurum
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.5 propanoyl-CoA + H2O + oxaloacetate
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 Mycolicibacterium neoaurum (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
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 ?
2.3.3.5 propanoyl-CoA + H2O + oxaloacetate the enzyme is involved in the 2-methylcitrate cycle pathway which plays a significant role in the detoxification of propionyl-CoA in bacteria Mycolicibacterium neoaurum (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.3.5 Methylcitrate synthase
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 Mycolicibacterium neoaurum
2.3.3.5 PrpC
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 Mycolicibacterium neoaurum

General Information

EC Number General Information Comment Organism
2.3.3.5 metabolism the enzyme is involved in the 2-methylcitrate cycle pathway which plays a significant role in the detoxification of propionyl-CoA in bacteria Mycolicibacterium neoaurum