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Literature summary extracted from

  • Yoo, M.; Croux, C.; Meynial-Salles, I.; Soucaille, P.
    Metabolic flexibility of a butyrate pathway mutant of Clostridium acetobutylicum (2017), Metab. Eng., 40, 138-147 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.2.7 ATP + butanoate Clostridium acetobutylicum
-
 ADP + butanoyl phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.19 Clostridium acetobutylicum P58255
-
-
2.3.1.19 Clostridium acetobutylicum DSM 792 P58255
-
-
2.7.2.7 Clostridium acetobutylicum Q45829
-
-
2.7.2.7 Clostridium acetobutylicum Q97II1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.2.7 ATP + butanoate
-
 Clostridium acetobutylicum ADP + butanoyl phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.19 PTB
-
 Clostridium acetobutylicum
2.7.2.7 buk1
-
 Clostridium acetobutylicum
2.7.2.7 Buk2
-
 Clostridium acetobutylicum

General Information

EC Number General Information Comment Organism
2.3.1.19 physiological function a butanoate kinase mutant is not viable if the ptb gene is not also inactivated. In a butanoate kinase/phosphate butanoyltransferase double mutant under acidogenic conditions, the primary metabolite is butanol and 2-hydroxyvalerate is produced. Under solventogenesis, 58% increased butanol production is obtained compared to the control, and 0.3 g/g butanol formation is reached. Under alcohologenesis, the major product is lactate. AdhE2, which encodes an aldehyde/alcohol dehydrogenase, is highly expressed in all metabolic states in the mutant Clostridium acetobutylicum
2.7.2.7 malfunction an enzyme-deficient mutant is not viable if the phosphotransbutyrylase gene is not also inactivated Clostridium acetobutylicum