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Literature summary extracted from

  • Yuan, F.; Zhang, L.; Cao, Y.; Gao, W.; Zhao, C.; Fang, Y.; Zahedi, K.; Soleimani, M.; Lu, X.; Fang, Z.; Yang, Q.
    Spermidine/spermine N1-acetyltransferase-mediated polyamine catabolism regulates beige adipocyte biogenesis (2018), Metab. Clin. Exp., 85, 298-304 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.57 N1, N11-diethylnorspermine
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.57 acetyl-CoA + spermidine Mus musculus
-
 CoA + N1-acetylspermidine
-
 ?
2.3.1.57 acetyl-CoA + spermine Mus musculus
-
 CoA + N1-acetylspermine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.57 Mus musculus P48026
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.57 adipocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.57 acetyl-CoA + spermidine
-
 Mus musculus CoA + N1-acetylspermidine
-
 ?
2.3.1.57 acetyl-CoA + spermine
-
 Mus musculus CoA + N1-acetylspermine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.57 SAT1
-
 Mus musculus
2.3.1.57 spermidine-spermine N1-acetyltransferase
-
 Mus musculus
2.3.1.57 spermidine/spermine N1-acetyltransferase
-
 Mus musculus

Expression

EC Number Organism Comment Expression
2.3.1.57 Mus musculus both cold and beta3-adrenergic receptor agonist CL-316,243 increase the expression of the enzyme in inguinal white adipose tissue and brown adipose tissue up

General Information

EC Number General Information Comment Organism
2.3.1.57 malfunction enzyme knockout mice develop late-onset obesity on a high-fat diet with impaired cold-induced beige adipocyte biogenesis and energy expenditure Mus musculus
2.3.1.57 physiological function enzyme activation plays a key role in cold and beta3-adrenergic receptor agonist-induced beige adipocyte biogenesis and low-grade inflammation. Enzyme activation enhances hydrogen peroxide production in adipocytes. Adipose enzyme regulates beige adipocyte thermogenesis Mus musculus