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Literature summary extracted from

  • Cai, J.; Liu, Z.; Huang, X.; Shu, S.; Hu, X.; Zheng, M.; Tang, C.; Liu, Y.; Chen, G.; Sun, L.; Liu, H.; Liu, F.; Cheng, J.; Dong, Z.
    The deacetylase sirtuin 6 protects against kidney fibrosis by epigenetically blocking beta-catenin targetgene expression (2020), Kidney Int., 97, 106-118 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.B41 additional information enzyme knockout by SIRT6 siRNA expression. SIRT6 overexpression in hepatocellular carcinoma cells reduces E-cadherin levels Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.B41 NAD+ + [protein]-N6-palmitoyl-L-lysine Homo sapiens
-
 nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.B41 Homo sapiens Q8N6T7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.B41 BEL-7402 cell
-
 Homo sapiens
-
2.3.1.B41 HCCLM-3 cell
-
 Homo sapiens
-
2.3.1.B41 HEP-3B cell
-
 Homo sapiens
-
2.3.1.B41 hepatoma cell HCC cell, SIRT6 upregulation is quite prevalent in HCC tissues and closely correlated with worse overall survival, disease-relapse free survival, and HCC metastasis Homo sapiens
-
2.3.1.B41 HL-7702 cell
-
 Homo sapiens
-
2.3.1.B41 liver
-
 Homo sapiens
-
2.3.1.B41 MHCC-97H cell
-
 Homo sapiens
-
2.3.1.B41 MHCC97-L cell
-
 Homo sapiens
-
2.3.1.B41 additional information SIRT6 promoted HCC metastasis, expression analysis in HCC cell lines, overview. SIRT6 expression is significantly increased. SIRT6 is also upregulated in Hep3B and LO2 cells Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.B41 NAD+ + [protein]-N6-palmitoyl-L-lysine
-
 Homo sapiens nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.B41 deacetylase sirtuin 6
-
 Homo sapiens
2.3.1.B41 SIRT6
-
 Homo sapiens
2.3.1.B41 Sirtuin6
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.B41 NAD+
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.B41 evolution sirtuin6 is a member of the sirtuin family which function as NAD+-dependent deacetylases Homo sapiens
2.3.1.B41 malfunction E-cadherin degradation and invasion, migration induced by SIRT6 overexpression can be rescued by dual mutation of Beclin-1 (inhibition of acetylation), CQ (autophagy inhibitor), and knockdown of Atg7 Homo sapiens
2.3.1.B41 physiological function sirtuin6 (SIRT6) is an NAD+-dependent deacetylase that targets a variety of proteins to regulate cellular processes and activities. Sirtuin family members are essential for tumor metastasis and epithelial-mesenchymal transition (EMT). Analysis of the mechanism by which SIRT6 facilitates EMT and metastasis, mechanism, overview. SIRT6 promotes HCC cell migration, invasion, and EMT. SIRT6 deacetylates Beclin-1 in HCC cells and this event leads to the promotion of the autophagic degradation of E-cadherin. SIRT6 also promotes N-cadherin and Vimentin expression via deacetylating FOXO3a in HCC. SIRT6 promotes the E-cadherin degradation in HCC via the lysosomal pathway, SIRT6 promotes the autophagic degradation of E-cadherin by deacetylating Beclin-1 Homo sapiens