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Literature summary extracted from

  • Saini, S.S.; Teotia, D.; Gaid, M.; Thakur, A.; Beerhues, L.; Sircar, D.
    Benzaldehyde dehydrogenase-driven phytoalexin biosynthesis in elicitor-treated Pyrus pyrifolia cell cultures (2017), J. Plant Physiol., 215, 154-162 .
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.28 0.00052
-
 benzaldehyde pH 9.5, 40°C Pyrus pyrifolia
1.2.1.28 0.064
-
 NAD+ pH 9.5, 40°C Pyrus pyrifolia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.28 benzaldehyde + NAD+ + H2O Pyrus pyrifolia the enzyme is involved in biphenyl phytoalexin biosynthesis. Pyrus pyrifolia cell cultures respond to yeast extract treatment by accumulating benzoate-derived biphenyl phytoalexins, namely, noraucuparin and aucuparin benzoate + NADH + 2 H+
-
 ?
2.3.1.177 3 malonyl-CoA + benzoyl-CoA Pyrus pyrifolia the enzyme is involved in biphenyl biosynthesis. Pyrus pyrifolia cell cultures respond to yeast extract treatment by accumulating benzoate-derived biphenyl phytoalexins, namely, noraucuparin and aucuparin 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.28 Pyrus pyrifolia
-
-
-
2.3.1.177 Pyrus pyrifolia
-
-
-

Storage Stability

EC Number Storage Stability Organism
1.2.1.28 -20°C, 24 h, significant loss in enzyme activity (70 %) upon storage of cell-free extract Pyrus pyrifolia

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.28 2-hydroxybenzaldehyde + NAD+ + H2O 2% realtive activity as compared to benzaldehyde Pyrus pyrifolia 2-hydroxybenzoate + NADH + 2 H+
-
 ?
1.2.1.28 3-hydroxybenzaldehyde + NAD+ + H2O 1.5% realtive activity as compared to benzaldehyde Pyrus pyrifolia 3-hydroxybenzoate + NADH + 2 H+
-
 ?
1.2.1.28 4-hydroxybenzaldehyde + NAD+ + H2O 14.7% realtive activity as compared to benzaldehyde Pyrus pyrifolia 4-hydroxybenzoate + NADH + 2 H+
-
 ?
1.2.1.28 acetaldehyde + NAD+ + H2O 25.8% realtive activity as compared to benzaldehyde Pyrus pyrifolia acetate + NADH + 2 H+
-
 ?
1.2.1.28 benzaldehyde + FAD + H2O the preferred cofactor is NAD+ followed by NADP+ (82%), FAD (40%) and FMN (34%) Pyrus pyrifolia benzoate + FADH2
-
 ?
1.2.1.28 benzaldehyde + FMN + H2O the preferred cofactor is NAD+ followed by NADP+ (82%), FAD (40%) and FMN (34%) Pyrus pyrifolia benzoate + FMNH2
-
 ?
1.2.1.28 benzaldehyde + NAD+ + H2O the enzyme is involved in biphenyl phytoalexin biosynthesis. Pyrus pyrifolia cell cultures respond to yeast extract treatment by accumulating benzoate-derived biphenyl phytoalexins, namely, noraucuparin and aucuparin Pyrus pyrifolia benzoate + NADH + 2 H+
-
 ?
1.2.1.28 benzaldehyde + NAD+ + H2O the preferred cofactor is NAD+ followed by NADP+ (82%), FAD (40%) and FMN (34%) Pyrus pyrifolia benzoate + NADH + 2 H+
-
 ?
1.2.1.28 benzaldehyde + NADP+ + H2O the preferred cofactor is NAD+ followed by NADP+ (82%), FAD (40%) and FMN (34%) Pyrus pyrifolia benzoate + NADPH + 2 H+
-
 ?
1.2.1.28 propionaldehyde + NAD+ + H2O 10% realtive activity as compared to benzaldehyde Pyrus pyrifolia propionate + NADH + 2 H+
-
 ?
2.3.1.177 3 malonyl-CoA + benzoyl-CoA
-
 Pyrus pyrifolia 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2
-
 ?
2.3.1.177 3 malonyl-CoA + benzoyl-CoA the enzyme is involved in biphenyl biosynthesis. Pyrus pyrifolia cell cultures respond to yeast extract treatment by accumulating benzoate-derived biphenyl phytoalexins, namely, noraucuparin and aucuparin Pyrus pyrifolia 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.28 benzaldehyde dehydrogenase
-
 Pyrus pyrifolia
2.3.1.177 biphenyl synthase
-
 Pyrus pyrifolia
2.3.1.177 BIS
-
 Pyrus pyrifolia

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.1.28 40
-
-
 Pyrus pyrifolia

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.28 9.5
-
-
 Pyrus pyrifolia

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.28 FAD the preferred cofactor is NAD+ followed by NADP+ (82%), FAD (40%) and FMN (34%) Pyrus pyrifolia
1.2.1.28 FMN the preferred cofactor is NAD+ followed by NADP+ (82%), FAD (40%) and FMN (34%) Pyrus pyrifolia
1.2.1.28 NAD+ the preferred cofactor is NAD+ followed by NADP+ (82%), FAD (40%) and FMN (34%) Pyrus pyrifolia
1.2.1.28 NADP+ the preferred cofactor is NAD+ followed by NADP+ (82%), FAD (40%) and FMN (34%) Pyrus pyrifolia

General Information

EC Number General Information Comment Organism
1.2.1.28 metabolism the enzyme is involved in biphenyl phytoalexin biosynthesis. Pyrus pyrifolia cell cultures respond to yeast extract treatment by accumulating benzoate-derived biphenyl phytoalexins, namely, noraucuparin and aucuparin Pyrus pyrifolia
2.3.1.177 metabolism the enzyme is involved in biphenyl biosynthesis. Pyrus pyrifolia cell cultures respond to yeast extract treatment by accumulating benzoate-derived biphenyl phytoalexins, namely, noraucuparin and aucuparin Pyrus pyrifolia