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Literature summary extracted from

  • Kurita, A.; Miyauchi, Y.; Ikushiro, S.; Mackenzie, P.I.; Yamada, H.; Ishii, Y.
    Comprehensive Characterization of mouse UDP-glucuronosyltransferase (Ugt) belonging to the Ugt2b subfamily identification of Ugt2b36 as the predominant isoform involved in morphine glucuronidation (2017), J. Pharmacol. Exp. Ther., 361, 199-208 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 expressed in a baculovirus-Sf9 cell system Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 0.00318
-
 17beta-estradiol isoform Ugt1a1, at pH 7.4 and 37°C Mus musculus
2.4.1.17 0.24
-
 morphine isoform Ugt2b36, at pH 7.4 and 37°C Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Mus musculus Q3UEP4
-
-
2.4.1.17 Mus musculus Q63886
-
-
2.4.1.17 Mus musculus Q8K154
-
-
2.4.1.17 Mus musculus Q8VCN3
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
 Mus musculus
-
2.4.1.17 liver isoform Ugt2b36 is highly expressed in the liver Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 17beta-estradiol + UDP-alpha-D-glucuronate
-
 Mus musculus UDP + estradiol-3beta-D-glucuronoside
-
 ?
2.4.1.17 4-methylumbelliferone + UDP-glucuronate
-
 Mus musculus UDP + 4-methylumbelliferyl beta-D-glucuronide
-
 ?
2.4.1.17 morphine + UDP-glucuronate
-
 Mus musculus UDP + morphine beta-D-glucuronide
-
 ?
2.4.1.17 morphine + UDP-glucuronate Ugt2b36 is the predominant isoform involved in morphine glucuronidation Mus musculus UDP + morphine beta-D-glucuronide
-
 ?
2.4.1.17 UDP-alpha-D-glucuronate + chloramphenicol
-
 Mus musculus UDP + chloramphenicol beta-D-glucuronide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase
-
 Mus musculus
2.4.1.17 UGT1A1 isoform Mus musculus
2.4.1.17 Ugt2b34 isoform Mus musculus
2.4.1.17 Ugt2b36 isoform Mus musculus
2.4.1.17 Ugt2b37 isoform Mus musculus