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Literature summary extracted from

  • Iwasaki, A.; Tadenuma, T.; Sumimoto, S.; Ohshiro, T.; Ozaki, K.; Kobayashi, K.; Teruya, T.; Tomoda, H.; Suenaga, K.
    Biseokeaniamides A, B, and C, sterol O-Acyltransferase inhibitors from an Okeania sp. marine cyanobacterium (2017), J. Nat. Prod., 80, 1161-1166 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.26 biseokeaniamide A
-
 Homo sapiens
2.3.1.26 biseokeaniamide B exhibits moderate cytotoxicity against HeLa cancer cells; exhibits moderate cytotoxicity against HeLa cancer cells Homo sapiens
2.3.1.26 biseokeaniamide C
-
 Homo sapiens
2.3.1.26 purpactin A
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Homo sapiens O75908 isoform SOAT2
-
2.3.1.26 Homo sapiens P35610 isoform SOAT1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 oleoyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesterol oleate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.26 SOAT!
-
 Homo sapiens
2.3.1.26 Soat2
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.26 0.0009
-
 enzyme-based assay, 37°C, pH not specified in the publication Homo sapiens purpactin A
2.3.1.26 0.000918
-
 enzyme-based assay, 37°C, pH not specified in the publication Homo sapiens purpactin A
2.3.1.26 0.0013
-
 cell-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide A
2.3.1.26 0.0015
-
 cell-based assay, 37°C, pH not specified in the publication Homo sapiens purpactin A
2.3.1.26 0.0018
-
 cell-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide A
2.3.1.26 0.0018
-
 enzyme-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide A
2.3.1.26 0.0025
-
 cell-based assay, 37°C, pH not specified in the publication Homo sapiens purpactin A
2.3.1.26 0.0025
-
 cell-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide B
2.3.1.26 0.0068
-
 enzyme-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide B
2.3.1.26 0.0069
-
 cell-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide B
2.3.1.26 0.0096
-
 enzyme-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide A
2.3.1.26 0.0099
-
 enzyme-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide B
2.3.1.26 0.011
-
 enzyme-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide C
2.3.1.26 0.012
-
 cell-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide C
2.3.1.26 0.032
-
 enzyme-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide C
2.3.1.26 0.096
-
 cell-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide C