Literature summary extracted from

Feng, Y.; Wong, L.; Morse, M.; Rouzina, I.; Williams, M.C.; Chelico, L.
RNA-mediated dimerization of the human deoxycytidine deaminase APOBEC3H influences enzyme activity and interaction with nucleic acids (2018), J. Mol. Biol., 430, 4891-4907 .

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.5.4.38	RNA	RNA binding is integral to APOBEC3H function. RNA-mediated dimerization alters the interactions of the enzyme with ssDNA and other RNA molecules	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.5.4.38	cytosine in single-stranded DNA + H2O	Homo sapiens	-	uracil in single-stranded DNA + NH3	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.5.4.38	Homo sapiens	Q6NTF7	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.5.4.38	cytosine in single-stranded DNA + H2O	-	Homo sapiens	uracil in single-stranded DNA + NH3	-	?
3.5.4.38	cytosine in single-stranded DNA + H2O	RNA binding is integral to APOBEC3H function. RNA-mediated dimerization alters the interactions of the enzyme with ssDNA and other RNA molecules	Homo sapiens	uracil in single-stranded DNA + NH3	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.5.4.38	APOBEC3H	-	Homo sapiens
3.5.4.38	single-stranded (ss)DNA deoxycytidine deaminase	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
3.5.4.38	malfunction	when aberrantly expressed in lung or breast tissue, APOBEC3H can contribute to cancer mutagenesis	Homo sapiens
3.5.4.38	physiological function	the enzyme inhibits replication of retroelements and HIV-1 in CD4+ T cells	Homo sapiens

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Release 2023.1 (January 2023)