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Literature summary extracted from

  • Babault, N.; Allali-Hassani, A.; Li, F.; Fan, J.; Yue, A.; Ju, K.; Liu, F.; Vedadi, M.; Liu, J.; Jin, J.
    Discovery of bisubstrate inhibitors of nicotinamide N-methyltransferase (NNMT) (2018), J. Med. Chem., 61, 1541-1551 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.1 expression in Escherichia coli Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.1.1.1 in complex with inhibitor 5'-[[(3S)-3-amino-3-carboxypropyl][(3-carbamoylphenyl)methyl]amino]-5'-deoxyadenosine Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.1 5'-[[(3S)-3-amino-3-carboxypropyl][(3-carbamoylphenyl)methyl]amino]-5'-deoxyadenosine bisubstrate inhibitor, competitive with respect to S-adenosyl-L-methionine, noncompetitive with respect to nicotinamide Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.1 0.02
-
 nicotinamide pH 7.5, temperature not specified in the publication Homo sapiens
2.1.1.1 0.024
-
 S-adenosyl-L-methionine pH 7.5, temperature not specified in the publication Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.1 Homo sapiens P40261
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.1 S-adenosyl-L-methionine + nicotinamide
-
 Homo sapiens S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.1.1.1 0.068
-
 S-adenosyl-L-methionine pH 7.5, temperature not specified in the publication Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.1.1.1 0.014
-
 pH 7.5, temperature not specified in the publication Homo sapiens 5'-[[(3S)-3-amino-3-carboxypropyl][(3-carbamoylphenyl)methyl]amino]-5'-deoxyadenosine