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Literature summary extracted from

  • Niu, M.; Wang, Y.; Wang, C.; Lyu, J.; Wang, Y.; Dong, H.; Long, W.; Wang, D.; Kong, W.; Wang, L.; Guo, X.; Sun, L.; Hu, T.; Zhai, H.; Wang, H.; Wan, J.
    ALR encoding dCMP deaminase is critical for DNA damage repair, cell cycle progression and plant development in rice (2017), J. Exp. Bot., 68, 5773-5786 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.4.12 expression in Escherichia coli BL21 (DE3) Oryza sativa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.12 dCMP + H2O Oryza sativa the enzyme is crucial to the production of dTTP needed for DNA replication and damage repair. It mediates dNTP pool balance required for normal chloroplast development and vegetative growth in plants dUMP + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.12 Oryza sativa Q5JN09 subsp. japonica
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.12
-
Oryza sativa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.12 dCMP + H2O
-
Oryza sativa dUMP + NH3
-
?
3.5.4.12 dCMP + H2O the enzyme is crucial to the production of dTTP needed for DNA replication and damage repair. It mediates dNTP pool balance required for normal chloroplast development and vegetative growth in plants Oryza sativa dUMP + NH3
-
?

Synonyms

EC Number Synonyms Comment Organism
3.5.4.12 DCD
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Oryza sativa
3.5.4.12 deoxycytidine monophosphate deaminase
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Oryza sativa

General Information

EC Number General Information Comment Organism
3.5.4.12 malfunction DELTA(DCD) protein in the alr mutant (albinic leaf and growth retardation) is a loss-of-function protein that lacks binding ability. Deoxycytidine monophosphate deaminase deficiency causes accumulation of DNA damage in the alr mutant, sometimes leading to cell apoptosis. Deoxycytidine monophosphate deaminase deficiency triggers cell cycle checkpoints and arrests cell progression at the G1/S-phase. Decreased cell proliferation and defective chloroplast development in the alr mutant is demonstrated. The expression of nuclear and plastid genome replication genes is down-regulated under decreased dTTP Oryza sativa
3.5.4.12 metabolism the enzyme is crucial to the production of dTTP needed for DNA replication and damage repair. It mediates dNTP pool balance required for normal chloroplast development and vegetative growth in plants Oryza sativa