EC Number | Cloned (Comment) | Organism |
---|---|---|
3.5.4.12 | expression in Escherichia coli BL21 (DE3) | Oryza sativa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.4.12 | dCMP + H2O | Oryza sativa | the enzyme is crucial to the production of dTTP needed for DNA replication and damage repair. It mediates dNTP pool balance required for normal chloroplast development and vegetative growth in plants | dUMP + NH3 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.4.12 | Oryza sativa | Q5JN09 | subsp. japonica | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.5.4.12 | - |
Oryza sativa |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.4.12 | dCMP + H2O | - |
Oryza sativa | dUMP + NH3 | - |
? | |
3.5.4.12 | dCMP + H2O | the enzyme is crucial to the production of dTTP needed for DNA replication and damage repair. It mediates dNTP pool balance required for normal chloroplast development and vegetative growth in plants | Oryza sativa | dUMP + NH3 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.4.12 | DCD | - |
Oryza sativa |
3.5.4.12 | deoxycytidine monophosphate deaminase | - |
Oryza sativa |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.5.4.12 | malfunction | DELTA(DCD) protein in the alr mutant (albinic leaf and growth retardation) is a loss-of-function protein that lacks binding ability. Deoxycytidine monophosphate deaminase deficiency causes accumulation of DNA damage in the alr mutant, sometimes leading to cell apoptosis. Deoxycytidine monophosphate deaminase deficiency triggers cell cycle checkpoints and arrests cell progression at the G1/S-phase. Decreased cell proliferation and defective chloroplast development in the alr mutant is demonstrated. The expression of nuclear and plastid genome replication genes is down-regulated under decreased dTTP | Oryza sativa |
3.5.4.12 | metabolism | the enzyme is crucial to the production of dTTP needed for DNA replication and damage repair. It mediates dNTP pool balance required for normal chloroplast development and vegetative growth in plants | Oryza sativa |