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Literature summary extracted from

  • Kokkonen, P.; Bednar, D.; Dockalova, V.; Prokop, Z.; Damborsky, J.
    Conformational changes allow processing of bulky substrates by a haloalkane dehalogenase with a small and buried active site (2018), J. Biol. Chem., 293, 11505-11512 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.8.1.5 F172W the conformational change of the mutant enzyme is faster than that of the wild-type enzyme. The open conformation is more common than the closed one. The closed conformation also displays a larger distance between the two helices than what is observed in the wild-type simulations Xanthobacter autotrophicus

Organism

EC Number Organism UniProt Comment Textmining
3.8.1.5 Xanthobacter autotrophicus P22643
-
-
3.8.1.5 Xanthobacter autotrophicus GJ10 P22643
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.8.1.5 1,2-dichloroethane + H2O
-
 Xanthobacter autotrophicus 2-chloro-1-ethanol + chloride
-
 ?
3.8.1.5 1,2-dichloroethane + H2O
-
 Xanthobacter autotrophicus GJ10 2-chloro-1-ethanol + chloride
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.8.1.5 DhlA
-
 Xanthobacter autotrophicus