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Literature summary extracted from

  • Asciolla, J.J.; Miele, M.M.; Hendrickson, R.C.; Resh, M.D.
    An in vitro fatty acylation assay reveals a mechanism for Wnt recognition by the acyltransferase porcupine (2017), J. Biol. Chem., 292, 13507-13513 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.250 2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide i.e. LGK-974. Directly inhibits PORCN-mediated Wnt acylation Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt]-L-serine Mus musculus
-
 CoA + [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.250 Mus musculus Q9JJJ7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt]-L-serine
-
 Mus musculus CoA + [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
2.3.1.250 [125I]iodo-pentadecenoyl-CoA + [Wnt]-L-serine [125I]iodo-pentadecenoyl-CoA is a radioiodinated palmitoleate analog Mus musculus CoA + [Wnt]-O-[125I]iodo-pentadecenoyl-L-serine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.250 porcupine
-
 Mus musculus