Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Venkataraman, K.; Riebeling, C.; Bodennec, J.; Riezman, H.; Allegood, J.C.; Sullards, M.C.; Merrill, A.H.Jr.; Futerman, A.H.
    Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells (2002), J. Biol. Chem., 277, 35642-35649 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.299 expressed in HEK-293T cells Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.299 (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.299 endoplasmic reticulum
-
 Mus musculus 5783
-
2.3.1.299 Golgi apparatus
-
 Mus musculus 5794
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.299 Mg2+ 2 mM used in assay conditions Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.299 stearoyl-CoA + sphinganine Mus musculus
-
 N-(stearoyl)-sphinganine + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.299 Mus musculus P27545
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.299 additional information no activity with palmitoyl-CoA Mus musculus ?
-
-
2.3.1.299 stearoyl-CoA + sphinganine
-
 Mus musculus N-(stearoyl)-sphinganine + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.299 (dihydro)ceramide synthase
-
 Mus musculus
2.3.1.299 UOG1 gene name, upstream of growth and differentiation factor-1 Mus musculus

General Information

EC Number General Information Comment Organism
2.3.1.299 metabolism the N-(stearoyl)-sphinganine produced by the enzyme most significantly impacts neutral glycosphingolipid synthesis Mus musculus