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Literature summary extracted from

  • Weinstein, J.; de Souza-e-Silva, U.; Paulson, J.
    Sialylation of glycoprotein oligosaccharides N-linked to asparagine. Enzymatic characterization of a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase and a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase from rat liver (1982), J. Biol. Chem., 257, 13845-13853 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.3.5 CMP-N-acetyl-beta-neuraminate + Galbeta(1->4)GlcNAc-R Rattus norvegicus
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 CMP + NeuAcalpa(2->6)Galbeta(1->4)GlcNAc-R
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.5 Rattus norvegicus
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.5 liver
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 Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.5 CMP-N-acetyl-beta-neuraminate + asialo-alpha1-acid glycoprotein 100% activity Rattus norvegicus ?
-
 ?
2.4.3.5 CMP-N-acetyl-beta-neuraminate + asialoprothrombin 100% activity Rattus norvegicus ?
-
 ?
2.4.3.5 CMP-N-acetyl-beta-neuraminate + asialotransferrin 82% activity Rattus norvegicus ?
-
 ?
2.4.3.5 CMP-N-acetyl-beta-neuraminate + Galbeta(1->4)GlcNAc-R
-
 Rattus norvegicus CMP + NeuAcalpa(2->6)Galbeta(1->4)GlcNAc-R
-
 ?
2.4.3.5 CMP-N-acetyl-beta-neuraminate + prothrombin 4% activity Rattus norvegicus ?
-
 ?
2.4.3.5 CMP-N-acetyl-beta-neuraminate + transferrin 6% activity Rattus norvegicus ?
-
 ?
2.4.3.5 additional information the enzyme is almost incapable of utilizing the Galbeta(1->3)GlcNAc sequence of asialoagalactoprothrombin as an acceptor and shows no activity towards asialoagalacto-alpha1-acid glycoprotein, antifreeze glycoprotein and asialo-ovine submaxillary mucin Rattus norvegicus ?
-
-

Synonyms

EC Number Synonyms Comment Organism
2.4.3.5 Galbeta1->4GlcNAcalpha2->6 sialyltransferase
-
 Rattus norvegicus