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Literature summary extracted from

  • Hori, H.; Terui, Y.; Nakamoto, C.; Iwashita, C.; Ochi, A.; Watanabe, K.; Oshima, T.
    Effects of polyamines from Thermus thermophilus, an extreme-thermophilic eubacterium, on tRNA methylation by tRNA (Gm18) methyltransferase (TrmH) (2016), J. Biochem., 159, 509-517 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.34 caldohexamine 1 mM caldohexamine increases TrmH activity at 60-80°C. No positive effect on the TrmH activity at 55°C Thermus thermophilus
2.1.1.34 Polyamine higher concentrations of linear polyamines inhibit TrmH activity at 55°C, while optimum concentration increases TrmH activity at 45-75°C Thermus thermophilus
2.1.1.34 tetrakis(3-aminopropyl)ammonium 0.25 mM, increases TrmH activity at 40-85°C Thermus thermophilus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.34 Polyamine higher concentrations of linear polyamines inhibit TrmH activity at 55°C, while optimum concentration increases TrmH activity at 45-75°C Thermus thermophilus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.34 Thermus thermophilus Q5SM16
-
-
2.1.1.34 Thermus thermophilus DSM 579 Q5SM16
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.34 S-adenosyl-L-methionine + guanosine18 in tRNAPhe substrate yeast tRNAPhe Thermus thermophilus S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNAPhe
-
 ?
2.1.1.34 S-adenosyl-L-methionine + guanosine18 in tRNAPhe substrate yeast tRNAPhe Thermus thermophilus DSM 579 S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNAPhe
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.34 TrmH
-
 Thermus thermophilus