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Literature summary extracted from

  • Liu, W.B.; Liu, X.X.; Shen, M.J.; She, G.L.; Ye, B.C.
    The nitrogen regulator GlnR directly controls transcription of the prpDBC operon involved in methylcitrate cycle in Mycobacterium smegmatis (2019), J. Bacteriol., 201, e00099-19 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.3.5 propanoyl-CoA + H2O + oxaloacetate Mycolicibacterium smegmatis the enzyme is specific to the methylcitrate cycle and essential for mycobacteria to grow on propionate as the sole carbon source (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.5 Mycolicibacterium smegmatis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.5 propanoyl-CoA + H2O + oxaloacetate
-
 Mycolicibacterium smegmatis (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
-
 ?
2.3.3.5 propanoyl-CoA + H2O + oxaloacetate the enzyme is specific to the methylcitrate cycle and essential for mycobacteria to grow on propionate as the sole carbon source Mycolicibacterium smegmatis (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.3.5 MCS
-
 Mycolicibacterium smegmatis
2.3.3.5 Methylcitrate synthase
-
 Mycolicibacterium smegmatis
2.3.3.5 PrpC
-
 Mycolicibacterium smegmatis

Expression

EC Number Organism Comment Expression
2.3.3.5 Mycolicibacterium smegmatis the nitrogen regulator GlnR regulates the methylcitrate cycle through direct repression of the transcription of the prpDBC operon down

General Information

EC Number General Information Comment Organism
2.3.3.5 metabolism the enzyme is specific to the methylcitrate cycle and essential for mycobacteria to grow on propionate as the sole carbon source Mycolicibacterium smegmatis