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Literature summary extracted from

  • Atila, M.; Katselis, G.; Chumala, P.; Luo, Y.
    Characterization of N-succinylation of L-lysylphosphatidylglycerol in Bacillus subtilis using tandem mass spectrometry (2016), J. Am. Soc. Mass Spectrom., 27, 1606-1613 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.3 L-lysyl-tRNALys + phosphatidylglycerol Bacillus subtilis
-
 tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol
-
 ?
2.3.2.3 L-lysyl-tRNALys + phosphatidylglycerol Bacillus subtilis 168
-
 tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.3 Bacillus subtilis C0H3X7
-
-
2.3.2.3 Bacillus subtilis 168 C0H3X7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.3 L-lysyl-tRNALys + phosphatidylglycerol
-
 Bacillus subtilis tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol
-
 ?
2.3.2.3 L-lysyl-tRNALys + phosphatidylglycerol
-
 Bacillus subtilis 168 tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.3 lysyl-PG synthase
-
 Bacillus subtilis
2.3.2.3 MprF
-
 Bacillus subtilis
2.3.2.3 phosphatidylglycerol lysyltransferase UniProt Bacillus subtilis

General Information

EC Number General Information Comment Organism
2.3.2.3 additional information compound determination by mass spectrometry Bacillus subtilis
2.3.2.3 physiological function in comparison with Gram-negative bacteria, Gram-positive bacteria in general have much less zwitterionic phosphatidylethanolamine. They are known for producing aminoacylated phosphatidylglycerol (PG), especially positively charged L-lysyl-PG, which is catalyzed by lysyl-PG synthase MprF. Enzyme MprF appears to have a broad range of specificity for L-aminoacyl transfer RNAs. Lipids from Bacillus subtilis are extremely abundant in lysyl-PG and somewhat rich in alanyl-PG. It appears that N-succinylation of lipids in Bacillus subtilis strain 168 is specific to lysyl-PG but not alanyl-PG Bacillus subtilis