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Literature summary extracted from

  • Mills, G.; Dumigan, A.; Kidd, T.; Hobley, L.; Bengoechea, J.
    Identification and characterization of two Klebsiella pneumoniae lpxL lipid A late acyltransferases and their role in virulence (2017), Infect. Immun., 85, e00068-17 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.3.1.241 drug development LpxL2 might be a candidate target in the development of anti-Klebsiella pneumoniae drugs Klebsiella pneumoniae

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.241 expression in Escherichia coli Klebsiella pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.241 Klebsiella pneumoniae W9B4X1
-
-
2.3.1.241 Klebsiella pneumoniae W9BFU2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.241 a dodecanoyl-[acyl-carrier protein] + Kdo2-lipid IVA
-
 Klebsiella pneumoniae dodecanoyl-Kdo2-lipid IVA + an [acyl-carrier protein]
-
 ?
2.3.1.241 a tetradecanoyl-[acyl-carrier protein] + Kdo2-lipid IVA
-
 Klebsiella pneumoniae tetradecanoyl-Kdo2-lipid IVA + an [acyl-carrier protein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.241 LpxL1
-
 Klebsiella pneumoniae
2.3.1.241 LpxL2
-
 Klebsiella pneumoniae

Expression

EC Number Organism Comment Expression
2.3.1.241 Klebsiella pneumoniae the enzyme (LpxL1) is negatively regulated by the two-component system PhoPQ down

General Information

EC Number General Information Comment Organism
2.3.1.241 malfunction lipid A produced by the lpxL2 mutant lacks the 2-hydroxymyristate, palmitate, and 4-aminoarabinose decorations found in the lipid A synthesized by the wild type. The lack of 2-hydroxymyristate is expected since LpxO modifies the myristate transferred by LpxL2 to the lipid A. The absence of the other two decorations is most likely caused by the downregulation of phoPQ and pmrAB expression Klebsiella pneumoniae
2.3.1.241 physiological function LpxL2-dependent lipid A acylation protects Klebsiella from polymyxins, mediates resistance to phagocytosis, limits the activation of inflammatory responses by macrophages, and is required for pathogen survival in the wax moth (Galleria mellonella). LpxL2 contribution to virulence is dependent on LpxO-mediated hydroxylation of the LpxL2-transferred myristate Klebsiella pneumoniae