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Literature summary extracted from

  • Thorsheim, K.; Persson, A.; Siegbahn, A.; Tykesson, E.; Westergren-Thorsson, G.; Mani, K.; Ellervik, U.
    Disubstituted naphthyl beta-D-xylopyranosides Synthesis, GAG priming, and histone acetyltransferase (HAT) inhibition (2016), Glycoconj. J., 33, 245-257 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.48 2-(6,7-dihydroxynaphthyl) beta-D-xylopyranoside less than 50% residual activity at 0.1 mM Homo sapiens
2.3.1.48 2-(6,7-dimethoxynaphthyl) beta-D-xylopyranoside about 80% residual activity at 0.1 mM Homo sapiens
2.3.1.48 2-(6-hydroxy-7-methoxy-naphthyl) beta-D-xylopyranoside less than 50% residual activity at 0.1 mM Homo sapiens
2.3.1.48 2-(7-hydroxy-6-methoxy-naphthyl) beta-D-xylopyranoside about 55% residual activity at 0.1 mM Homo sapiens
2.3.1.48 anacardic acid
-
 Homo sapiens
2.3.1.48 curcumin
-
 Homo sapiens
2.3.1.48 garcinol
-
 Homo sapiens
2.3.1.48 additional information the enzyme is not inhibited by xyloside-primed GAG chains Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.48 acetyl-CoA + [histone H3]-L-lysine Homo sapiens
-
 CoA + [histone H3]-N6-acetyl-L-lysine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.48 CCD-1095Sk cell
-
 Homo sapiens
-
2.3.1.48 HCC-70 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + [histone H3]-L-lysine
-
 Homo sapiens CoA + [histone H3]-N6-acetyl-L-lysine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 HAT
-
 Homo sapiens