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Literature summary extracted from

  • Sudo, G.; Kagawa, T.; Kokubu, Y.; Inazawa, J.; Taga, T.
    Increase in GFAP-positive astrocytes in histone demethylase GASC1/KDM4C/JMJD2C hypomorphic mutant mice (2016), Genes Cells, 21, 218-225 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 Mus musculus overall reaction [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 Mus musculus
-
 [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 Mus musculus
-
 [histone H3]-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Mus musculus
-
 [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.66 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 overall reaction Mus musculus [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Mus musculus [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
-
 Mus musculus [histone H3]-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
1.14.11.66 [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Mus musculus [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.66 GASC1
-
 Mus musculus
1.14.11.66 JMJD2C
-
 Mus musculus
1.14.11.66 Kdm4c
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.14.11.66 malfunction enzyme Gasc1 hypomorphic mutant mice exhibit abnormal behaviors including hyperactivity, persistence and many types of learning and memory deficits and abnormal synaptic functions such as prolonged long-term potentiation. Reduced expression of enzyme Gasc1 induces an increase in the number of glial fibrillary acidic protein-positive astrocytes from postnatal day 30 to months 2-3 Mus musculus