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Literature summary extracted from

  • Thiaville, J.J.; Frelin, O.; Garcia-Salinas, C.; Harrison, K.; Hasnain, G.; Horenstein, N.A.; Diaz de la Garza, R.I.; Henry, C.S.; Hanson, A.D.; de Crecy-Lagard, V.
    Experimental and metabolic modeling evidence for a folate-cleaving side-activity of ketopantoate hydroxymethyltransferase (PanB) (2016), Front. Microbiol., 7, 431 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.2.11 expressed in Escherichia coli strain BW25113 or MG1655 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.11 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O Escherichia coli
-
tetrahydrofolate + 2-dehydropantoate
-
?
2.1.2.11 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O Escherichia coli W3110
-
tetrahydrofolate + 2-dehydropantoate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.11 Escherichia coli
-
-
-
2.1.2.11 Escherichia coli W3110
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.11 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O
-
Escherichia coli tetrahydrofolate + 2-dehydropantoate
-
?
2.1.2.11 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O
-
Escherichia coli W3110 tetrahydrofolate + 2-dehydropantoate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.1.2.11 ketopantoate hydroxymethyltransferase
-
Escherichia coli
2.1.2.11 PanB
-
Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.11 5,10-methenyltetrahydrofolate dependent on Escherichia coli

General Information

EC Number General Information Comment Organism
2.1.2.11 metabolism enzyme overexpression leads to accumulation of the likely folate cleavage product 6-hydroxymethylpterin and other pterins in cells and medium, and to a 46% increase in total folate content Escherichia coli