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Literature summary extracted from

  • Han, X.; Chen, C.; Yan, Q.; Jia, L.; Taj, A.; Ma, Y.
    Action of dicumarol on glucosamine-1-phosphate acetyltransferase of GlmU and Mycobacterium tuberculosis (2019), Front. Microbiol., 10, 1799 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.157 expression in Escherichia coli Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.157 dicumarol uncompetitively inhibits acetyl CoA and shows mixed-type inhibition for glucosamine-1-phosphate. Dicumarol also exhibits inhibitory effects on several clinically sensitive Mycobacterium tuberculosis strains and drug-resistant strains, with a range of MIC value of 6.25 to more than 100 mg/ml. Dicumarol increases the sensitivity of anti-tuberculosis drugs (isoniazid and rifampicin) when dicumarol is present at a low concentration Mycobacterium tuberculosis
2.7.7.23 additional information dicumarol is unable to inhibit the N-acetylglucosamine-1-phosphate uridyltransferase activity of GlmU Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.157 acetyl-CoA + alpha-D-glucosamine 1-phosphate Mycobacterium tuberculosis
-
 CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 ?
2.3.1.157 acetyl-CoA + alpha-D-glucosamine 1-phosphate Mycobacterium tuberculosis ATCC 25177
-
 CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 ?
2.7.7.23 UTP + N-acetyl-alpha-D-glucosamine 1-phosphate Mycobacterium tuberculosis
-
 diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?
2.7.7.23 UTP + N-acetyl-alpha-D-glucosamine 1-phosphate Mycobacterium tuberculosis ATCC 25177
-
 diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.157 Mycobacterium tuberculosis A5U161
-
-
2.3.1.157 Mycobacterium tuberculosis ATCC 25177 A5U161
-
-
2.7.7.23 Mycobacterium tuberculosis A5U161
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.157 acetyl-CoA + alpha-D-glucosamine 1-phosphate
-
 Mycobacterium tuberculosis CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 ?
2.3.1.157 acetyl-CoA + alpha-D-glucosamine 1-phosphate
-
 Mycobacterium tuberculosis ATCC 25177 CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 ?
2.7.7.23 UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 Mycobacterium tuberculosis diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?
2.7.7.23 UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 Mycobacterium tuberculosis ATCC 25177 diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.157 GlmU
-
 Mycobacterium tuberculosis
2.3.1.157 glucosamine-1-phosphate acetyltransferase
-
 Mycobacterium tuberculosis
2.7.7.23 GlmU bifunctional enzyme with glucosamine-1-phosphate acetyltransferase activity and N-acetylglucosamine-1-phosphate uridyltransferase activity Mycobacterium tuberculosis
2.7.7.23 N-acetylglucosamine-1-phosphate uridyltransferase
-
 Mycobacterium tuberculosis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.157 0.0137
-
 pH 7.5, 37°C Mycobacterium tuberculosis dicumarol