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Literature summary extracted from

  • Saroha, A.; Pewzner-Jung, Y.; Ferreira, N.S.; Sharma, P.; Jouan, Y.; Kelly, S.L.; Feldmesser, E.; Merrill, A.H.; Trottein, F.; Paget, C.; Lang, K.S.; Futerman, A.H.
    Critical role for very-long chain sphingolipids in invariant natural killer T cell development and homeostasis (2017), Front. Immunol., 8, 1386 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.297 a very-long-chain fatty acyl-CoA + a sphingoid base Mus musculus
-
 a very-long-chain ceramide + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.297 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.297 a very-long-chain fatty acyl-CoA + a sphingoid base
-
 Mus musculus a very-long-chain ceramide + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.297 ceramide synthase 2
-
 Mus musculus
2.3.1.297 CerS2
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.3.1.297 malfunction enzyme-deficient mice show increased susceptibility to LCMV infection. Reduced levels of invariant natural killer T cells in the thymus of enzyme-null mice is due to their impaired maturation in the thymus Mus musculus