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Literature summary extracted from

  • Okado, N.; Sugi, M.; Ueda, M.; Mizuhashi, F.; Lynch, B.S.; Vo, T.D.; Roberts, A.S.
    Safety evaluation of AMP deaminase from Aspergillus oryzae (2015), Food Chem. Toxicol., 86, 342-350 .
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.4.6 food industry noting the use of the enzyme from Aspergillus oryzae in food intended for human consumption and potential presence at trace levels in finished goods, a series of safety studies including an in vitro Ames test and chromosome aberration assay with Chinese hamster lung fibroblasts are conducted along with a 90-day oral toxicity study in rats. AMP deaminase shows no evidence of genotoxicity in the in vitro tests. Following gavage administration of Sprague-Dawley rats at dosages of 19.8, 198.4, or 1984 mg total organic solids (TOS)/kg body weight (bw)/day for 90 days, no adverse effects on body weight gain, food consumption, hematology, clinical chemistry, urinalysis, ophthalmological and histopathological examinations are observed. The no-observed-adverse-effect level is considered to be 1984 mg TOS/kg bw/day, the highest dose tested. Results of the genotoxicity studies and subchronic rat study support the safe use of AMP deaminase produced from Aspergillus oryzae in food production Aspergillus oryzae

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.6 Aspergillus oryzae
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3.5.4.6 Aspergillus oryzae DEA262
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Synonyms

EC Number Synonyms Comment Organism
3.5.4.6 adenosine-5'-monophosphate deaminase
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 Aspergillus oryzae