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Literature summary extracted from

  • Delgado-Carmona, J.D.; Ramirez-Quijas, M.D.; Vega-Gonzalez, A.; Lopez-Romero, E.; Cuellar-Cruz, M.
    Changes in GDPase/UDPase enzymatic activity in response to oxidative stress in four Candida species (2015), Folia Microbiol. (Praha), 60, 343-350 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.6 H2O2 in the presence of H2O2, UDPase activity is lower than that of GDPase. GDPase activity significantly decreases at high concentrations. Inverse relationship between the decline in UDPase activity and the increase in the concentration of H2O2 Candida albicans
3.6.1.6 H2O2 in the presence of H2O2, UDPase activity is lower than that of GDPase. GDPase activity significantly decreases at high concentrations. Inverse relationship between the decline in UDPase activity and the increase in the concentration of H2O2 [Candida] glabrata
3.6.1.6 H2O2 in the presence of H2O2, UDPase activity is lower than that of GDPase. GDPase activity significantly decreases at high concentrations. Inverse relationship between the decline in UDPase activity and the increase in the concentration of H2O2 Candida parapsilosis
3.6.1.6 H2O2 in the presence of H2O2, UDPase activity is lower than that of GDPase. GDPase activity significantly decreases at high concentrations. Inverse relationship between the decline in UDPase activity and the increase in the concentration of H2O2 Pichia kudriavzevii
3.6.1.6 menadione
-
 Candida albicans
3.6.1.6 menadione UDPase activity increases at lower concentrations of the oxidant and decreases at higher concentrations [Candida] glabrata
3.6.1.6 menadione UDPase activity increases at lower concentrations of the oxidant and decreases at higher concentrations Candida parapsilosis
3.6.1.6 menadione
-
 Pichia kudriavzevii
3.6.1.6 additional information GDPase and UDPase activities are generally affected by H2O2 and the superoxide ion generated by menadione Candida albicans
3.6.1.6 additional information GDPase and UDPase activities are generally affected by H2O2 and the superoxide ion generated by menadione [Candida] glabrata
3.6.1.6 additional information GDPase and UDPase activities are generally affected by H2O2 and the superoxide ion generated by menadione Candida parapsilosis
3.6.1.6 additional information GDPase and UDPase activities are generally affected by H2O2 and the superoxide ion generated by menadione Pichia kudriavzevii
3.6.1.6 superoxide GDPase activity significantly decreases at high concentrations Candida albicans
3.6.1.6 superoxide GDPase activity significantly decreases at high concentrations [Candida] glabrata
3.6.1.6 superoxide GDPase activity significantly decreases at high concentrations Candida parapsilosis
3.6.1.6 superoxide GDPase activity significantly decreases at high concentrations Pichia kudriavzevii

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.1.6 microsome
-
 Pichia kudriavzevii
-
-
3.6.1.6 microsome
-
 Candida albicans
-
-
3.6.1.6 microsome
-
 Candida parapsilosis
-
-
3.6.1.6 microsome
-
 [Candida] glabrata
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.6 Ca2+ required Pichia kudriavzevii
3.6.1.6 Ca2+ required Candida albicans
3.6.1.6 Ca2+ required Candida parapsilosis
3.6.1.6 Ca2+ required [Candida] glabrata

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.6 GDP + H2O Pichia kudriavzevii
-
 GMP + phosphate
-
 ?
3.6.1.6 GDP + H2O Candida albicans
-
 GMP + phosphate
-
 ?
3.6.1.6 GDP + H2O Candida parapsilosis
-
 GMP + phosphate
-
 ?
3.6.1.6 GDP + H2O [Candida] glabrata
-
 GMP + phosphate
-
 ?
3.6.1.6 UDP + H2O Pichia kudriavzevii
-
 UMP + phosphate
-
 ?
3.6.1.6 UDP + H2O Candida albicans
-
 UMP + phosphate
-
 ?
3.6.1.6 UDP + H2O Candida parapsilosis
-
 UMP + phosphate
-
 ?
3.6.1.6 UDP + H2O [Candida] glabrata
-
 UMP + phosphate
-
 ?
3.6.1.42 GDP + H2O Pichia kudriavzevii
-
 GMP + phosphate
-
 ?
3.6.1.42 GDP + H2O Candida albicans
-
 GMP + phosphate
-
 ?
3.6.1.42 GDP + H2O Candida parapsilosis
-
 GMP + phosphate
-
 ?
3.6.1.42 GDP + H2O [Candida] glabrata
-
 GMP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.6 Candida albicans
-
 clinical isolate from Mexico
-
3.6.1.6 Candida parapsilosis
-
 clinical isolate from Mexico
-
3.6.1.6 Pichia kudriavzevii
-
 clinical isolate from Mexico
-
3.6.1.6 [Candida] glabrata
-
 clinical isolate from Mexico
-
3.6.1.42 Candida albicans
-
-
-
3.6.1.42 Candida parapsilosis
-
-
-
3.6.1.42 Pichia kudriavzevii
-
-
-
3.6.1.42 [Candida] glabrata
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.6 GDP + H2O
-
 Pichia kudriavzevii GMP + phosphate
-
 ?
3.6.1.6 GDP + H2O
-
 Candida albicans GMP + phosphate
-
 ?
3.6.1.6 GDP + H2O
-
 Candida parapsilosis GMP + phosphate
-
 ?
3.6.1.6 GDP + H2O
-
 [Candida] glabrata GMP + phosphate
-
 ?
3.6.1.6 UDP + H2O
-
 Pichia kudriavzevii UMP + phosphate
-
 ?
3.6.1.6 UDP + H2O
-
 Candida albicans UMP + phosphate
-
 ?
3.6.1.6 UDP + H2O
-
 Candida parapsilosis UMP + phosphate
-
 ?
3.6.1.6 UDP + H2O
-
 [Candida] glabrata UMP + phosphate
-
 ?
3.6.1.42 GDP + H2O
-
 Pichia kudriavzevii GMP + phosphate
-
 ?
3.6.1.42 GDP + H2O
-
 Candida albicans GMP + phosphate
-
 ?
3.6.1.42 GDP + H2O
-
 Candida parapsilosis GMP + phosphate
-
 ?
3.6.1.42 GDP + H2O
-
 [Candida] glabrata GMP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.6 GDPase
-
 Pichia kudriavzevii
3.6.1.6 GDPase
-
 Candida albicans
3.6.1.6 GDPase
-
 Candida parapsilosis
3.6.1.6 GDPase
-
 [Candida] glabrata
3.6.1.6 GDPase/UDPase
-
 Pichia kudriavzevii
3.6.1.6 GDPase/UDPase
-
 Candida albicans
3.6.1.6 GDPase/UDPase
-
 Candida parapsilosis
3.6.1.6 GDPase/UDPase
-
 [Candida] glabrata
3.6.1.6 NDPase
-
 Pichia kudriavzevii
3.6.1.6 NDPase
-
 Candida albicans
3.6.1.6 NDPase
-
 Candida parapsilosis
3.6.1.6 NDPase
-
 [Candida] glabrata
3.6.1.6 UDPase
-
 Pichia kudriavzevii
3.6.1.6 UDPase
-
 Candida albicans
3.6.1.6 UDPase
-
 Candida parapsilosis
3.6.1.6 UDPase
-
 [Candida] glabrata
3.6.1.42 GDPase
-
 Pichia kudriavzevii
3.6.1.42 GDPase
-
 Candida albicans
3.6.1.42 GDPase
-
 Candida parapsilosis
3.6.1.42 GDPase
-
 [Candida] glabrata

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.6.1.6 37
-
 assay at Pichia kudriavzevii
3.6.1.6 37
-
 assay at Candida albicans
3.6.1.6 37
-
 assay at Candida parapsilosis
3.6.1.6 37
-
 assay at [Candida] glabrata

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.1.6 7.5
-
 assay at Pichia kudriavzevii
3.6.1.6 7.5
-
 assay at Candida albicans
3.6.1.6 7.5
-
 assay at Candida parapsilosis
3.6.1.6 7.5
-
 assay at [Candida] glabrata

Expression

EC Number Organism Comment Expression
3.6.1.42 Pichia kudriavzevii the enzyme activity significantly decreases at high concentrations of menadione, H2O2 and O2- down
3.6.1.42 Candida albicans the enzyme activity significantly decreases at high concentrations of menadione, H2O2 and O2- down
3.6.1.42 Candida parapsilosis the enzyme activity significantly decreases at high concentrations of menadione, H2O2 and O2- down
3.6.1.42 [Candida] glabrata the enzyme activity significantly decreases at high concentrations of menadione, H2O2 and O2- down

General Information

EC Number General Information Comment Organism
3.6.1.6 metabolism the organism shows a basic mechanism to cope with oxidative stress, suggesting that the pathogen might activate mechanisms for UDPase synthesis at lower concentrations of superoxide. Differential response to oxidative stress by different Candida species, overview Pichia kudriavzevii
3.6.1.6 metabolism the organism shows a basic mechanism to cope with oxidative stress, suggesting that the pathogen might activate mechanisms for UDPase synthesis at lower concentrations of superoxide. Differential response to oxidative stress by different Candida species, overview Candida albicans
3.6.1.6 metabolism the organism shows a basic mechanism to cope with oxidative stress, suggesting that the pathogen might activate mechanisms for UDPase synthesis at lower concentrations of superoxide. Differential response to oxidative stress by different Candida species, overview Candida parapsilosis
3.6.1.6 metabolism the organism shows a basic mechanism to cope with oxidative stress, suggesting that the pathogen might activate mechanisms for UDPase synthesis at lower concentrations of superoxide. Differential response to oxidative stress by different Candida species, overview [Candida] glabrata
3.6.1.6 physiological function the terminal processing of proteins and lipids occurs in the Golgi apparatus and involves the transport of sugar nucleotides into the Golgi lumen by specific carriers and the accumulation of nucleoside diphosphates (NDPs) as a result of oligosaccharide-protein glycosyltransferase activity. NDPs are converted into the corresponding nucleoside monophosphates (NMPs) by nucleoside diphosphatases (NDPases), thus relieving inhibition of sugar transferases. NMPs are then exchanged for equimolecular amounts of cytosolic sugar nucleotides by antiport transport systems. NDPases, commonly GDPase and UDPase, thus play a critical role in glycoprotein maturation and may influence fungal pathogenesis, morphogenesis, and cell wall properties Pichia kudriavzevii
3.6.1.6 physiological function the terminal processing of proteins and lipids occurs in the Golgi apparatus and involves the transport of sugar nucleotides into the Golgi lumen by specific carriers and the accumulation of nucleoside diphosphates (NDPs) as a result of oligosaccharide-protein glycosyltransferase activity. NDPs are converted into the corresponding nucleoside monophosphates (NMPs) by nucleoside diphosphatases (NDPases), thus relieving inhibition of sugar transferases. NMPs are then exchanged for equimolecular amounts of cytosolic sugar nucleotides by antiport transport systems. NDPases, commonly GDPase and UDPase, thus play a critical role in glycoprotein maturation and may influence fungal pathogenesis, morphogenesis, and cell wall properties Candida albicans
3.6.1.6 physiological function the terminal processing of proteins and lipids occurs in the Golgi apparatus and involves the transport of sugar nucleotides into the Golgi lumen by specific carriers and the accumulation of nucleoside diphosphates (NDPs) as a result of oligosaccharide-protein glycosyltransferase activity. NDPs are converted into the corresponding nucleoside monophosphates (NMPs) by nucleoside diphosphatases (NDPases), thus relieving inhibition of sugar transferases. NMPs are then exchanged for equimolecular amounts of cytosolic sugar nucleotides by antiport transport systems. NDPases, commonly GDPase and UDPase, thus play a critical role in glycoprotein maturation and may influence fungal pathogenesis, morphogenesis, and cell wall properties Candida parapsilosis
3.6.1.6 physiological function the terminal processing of proteins and lipids occurs in the Golgi apparatus and involves the transport of sugar nucleotides into the Golgi lumen by specific carriers and the accumulation of nucleoside diphosphates (NDPs) as a result of oligosaccharide-protein glycosyltransferase activity. NDPs are converted into the corresponding nucleoside monophosphates (NMPs) by nucleoside diphosphatases (NDPases), thus relieving inhibition of sugar transferases. NMPs are then exchanged for equimolecular amounts of cytosolic sugar nucleotides by antiport transport systems. NDPases, commonly GDPase and UDPase, thus play a critical role in glycoprotein maturation and may influence fungal pathogenesis, morphogenesis, and cell wall properties [Candida] glabrata