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Literature summary extracted from

  • Su, D.; Ojo, T.T.; Soell, D.; Hohn, M.J.
    Selenomodification of tRNA in archaea requires a bipartite rhodanese enzyme (2012), FEBS Lett., 586, 717-721 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O Methanocaldococcus jannaschii
-
 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O Methanococcus aeolicus
-
 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O Methanococcus maripaludis
-
 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O Methanococcus voltae
-
 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O Methanococcus vannielii
-
 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O Methanocaldococcus fervens
-
 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O Methanocaldococcus infernus
-
 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O Methanocaldococcus vulcanius
-
 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O Methanocaldococcus sp. FS406-22
-
 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O Methanothermococcus okinawensis
-
 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.9.1.3 Methanocaldococcus fervens
-
-
-
2.9.1.3 Methanocaldococcus infernus
-
-
-
2.9.1.3 Methanocaldococcus jannaschii
-
-
-
2.9.1.3 Methanocaldococcus sp. FS406-22
-
-
-
2.9.1.3 Methanocaldococcus vulcanius
-
-
-
2.9.1.3 Methanococcus aeolicus
-
-
-
2.9.1.3 Methanococcus maripaludis
-
-
-
2.9.1.3 Methanococcus maripaludis Q6LYT8 ATP/GTP-binding site motif A (P-loop)
-
2.9.1.3 Methanococcus vannielii
-
-
-
2.9.1.3 Methanococcus voltae
-
-
-
2.9.1.3 Methanothermococcus okinawensis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O
-
 Methanocaldococcus jannaschii 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O
-
 Methanococcus aeolicus 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O
-
 Methanococcus maripaludis 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O
-
 Methanococcus voltae 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O
-
 Methanococcus vannielii 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O
-
 Methanocaldococcus fervens 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O
-
 Methanocaldococcus infernus 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O
-
 Methanocaldococcus vulcanius 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O
-
 Methanocaldococcus sp. FS406-22 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?
2.9.1.3 selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine34 in tRNA + H2O
-
 Methanothermococcus okinawensis 5-methylaminomethyl-2-selenouridine34 in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
-
 ?

General Information

EC Number General Information Comment Organism
2.9.1.3 evolution the putative bipartite ortholog of the bacterial YbbB gene is identified in twelve additional archaeal genomes. Its function is confirmed as a tRNA 2-selenouridine synthase through biochemical and genetic experiments. A phylogenetic analysis of bacterial and archaeal versions of this enzyme provides insights into the early evolution of tRNA 2-selenouridine synthase. The active site loop containing the YbbB-characteristic CXRGGXRS motif near the C-terminus of the rhodanese domain and the Walker A motif (GX4GKT) at the N-terminus of the P-loop domain are highly conserved among the archaeal and bacterial YbbB sequences. The identified archaeal YbbB orthologs represent a bipartite version of bacterial tRNA 2-selenouridine synthase Methanocaldococcus jannaschii
2.9.1.3 evolution the putative bipartite ortholog of the bacterial YbbB gene is identified in twelve additional archaeal genomes. Its function is confirmed as a tRNA 2-selenouridine synthase through biochemical and genetic experiments. A phylogenetic analysis of bacterial and archaeal versions of this enzyme provides insights into the early evolution of tRNA 2-selenouridine synthase. The active site loop containing the YbbB-characteristic CXRGGXRS motif near the C-terminus of the rhodanese domain and the Walker A motif (GX4GKT) at the N-terminus of the P-loop domain are highly conserved among the archaeal and bacterial YbbB sequences. The identified archaeal YbbB orthologs represent a bipartite version of bacterial tRNA 2-selenouridine synthase Methanococcus aeolicus
2.9.1.3 evolution the putative bipartite ortholog of the bacterial YbbB gene is identified in twelve additional archaeal genomes. Its function is confirmed as a tRNA 2-selenouridine synthase through biochemical and genetic experiments. A phylogenetic analysis of bacterial and archaeal versions of this enzyme provides insights into the early evolution of tRNA 2-selenouridine synthase. The active site loop containing the YbbB-characteristic CXRGGXRS motif near the C-terminus of the rhodanese domain and the Walker A motif (GX4GKT) at the N-terminus of the P-loop domain are highly conserved among the archaeal and bacterial YbbB sequences. The identified archaeal YbbB orthologs represent a bipartite version of bacterial tRNA 2-selenouridine synthase Methanococcus maripaludis
2.9.1.3 evolution the putative bipartite ortholog of the bacterial YbbB gene is identified in twelve additional archaeal genomes. Its function is confirmed as a tRNA 2-selenouridine synthase through biochemical and genetic experiments. A phylogenetic analysis of bacterial and archaeal versions of this enzyme provides insights into the early evolution of tRNA 2-selenouridine synthase. The active site loop containing the YbbB-characteristic CXRGGXRS motif near the C-terminus of the rhodanese domain and the Walker A motif (GX4GKT) at the N-terminus of the P-loop domain are highly conserved among the archaeal and bacterial YbbB sequences. The identified archaeal YbbB orthologs represent a bipartite version of bacterial tRNA 2-selenouridine synthase Methanococcus voltae
2.9.1.3 evolution the putative bipartite ortholog of the bacterial YbbB gene is identified in twelve additional archaeal genomes. Its function is confirmed as a tRNA 2-selenouridine synthase through biochemical and genetic experiments. A phylogenetic analysis of bacterial and archaeal versions of this enzyme provides insights into the early evolution of tRNA 2-selenouridine synthase. The active site loop containing the YbbB-characteristic CXRGGXRS motif near the C-terminus of the rhodanese domain and the Walker A motif (GX4GKT) at the N-terminus of the P-loop domain are highly conserved among the archaeal and bacterial YbbB sequences. The identified archaeal YbbB orthologs represent a bipartite version of bacterial tRNA 2-selenouridine synthase Methanococcus vannielii
2.9.1.3 evolution the putative bipartite ortholog of the bacterial YbbB gene is identified in twelve additional archaeal genomes. Its function is confirmed as a tRNA 2-selenouridine synthase through biochemical and genetic experiments. A phylogenetic analysis of bacterial and archaeal versions of this enzyme provides insights into the early evolution of tRNA 2-selenouridine synthase. The active site loop containing the YbbB-characteristic CXRGGXRS motif near the C-terminus of the rhodanese domain and the Walker A motif (GX4GKT) at the N-terminus of the P-loop domain are highly conserved among the archaeal and bacterial YbbB sequences. The identified archaeal YbbB orthologs represent a bipartite version of bacterial tRNA 2-selenouridine synthase Methanocaldococcus fervens
2.9.1.3 evolution the putative bipartite ortholog of the bacterial YbbB gene is identified in twelve additional archaeal genomes. Its function is confirmed as a tRNA 2-selenouridine synthase through biochemical and genetic experiments. A phylogenetic analysis of bacterial and archaeal versions of this enzyme provides insights into the early evolution of tRNA 2-selenouridine synthase. The active site loop containing the YbbB-characteristic CXRGGXRS motif near the C-terminus of the rhodanese domain and the Walker A motif (GX4GKT) at the N-terminus of the P-loop domain are highly conserved among the archaeal and bacterial YbbB sequences. The identified archaeal YbbB orthologs represent a bipartite version of bacterial tRNA 2-selenouridine synthase Methanocaldococcus infernus
2.9.1.3 evolution the putative bipartite ortholog of the bacterial YbbB gene is identified in twelve additional archaeal genomes. Its function is confirmed as a tRNA 2-selenouridine synthase through biochemical and genetic experiments. A phylogenetic analysis of bacterial and archaeal versions of this enzyme provides insights into the early evolution of tRNA 2-selenouridine synthase. The active site loop containing the YbbB-characteristic CXRGGXRS motif near the C-terminus of the rhodanese domain and the Walker A motif (GX4GKT) at the N-terminus of the P-loop domain are highly conserved among the archaeal and bacterial YbbB sequences. The identified archaeal YbbB orthologs represent a bipartite version of bacterial tRNA 2-selenouridine synthase Methanocaldococcus vulcanius
2.9.1.3 evolution the putative bipartite ortholog of the bacterial YbbB gene is identified in twelve additional archaeal genomes. Its function is confirmed as a tRNA 2-selenouridine synthase through biochemical and genetic experiments. A phylogenetic analysis of bacterial and archaeal versions of this enzyme provides insights into the early evolution of tRNA 2-selenouridine synthase. The active site loop containing the YbbB-characteristic CXRGGXRS motif near the C-terminus of the rhodanese domain and the Walker A motif (GX4GKT) at the N-terminus of the P-loop domain are highly conserved among the archaeal and bacterial YbbB sequences. The identified archaeal YbbB orthologs represent a bipartite version of bacterial tRNA 2-selenouridine synthase Methanocaldococcus sp. FS406-22
2.9.1.3 evolution the putative bipartite ortholog of the bacterial YbbB gene is identified in twelve additional archaeal genomes. Its function is confirmed as a tRNA 2-selenouridine synthase through biochemical and genetic experiments. A phylogenetic analysis of bacterial and archaeal versions of this enzyme provides insights into the early evolution of tRNA 2-selenouridine synthase. The active site loop containing the YbbB-characteristic CXRGGXRS motif near the C-terminus of the rhodanese domain and the Walker A motif (GX4GKT) at the N-terminus of the P-loop domain are highly conserved among the archaeal and bacterial YbbB sequences. The identified archaeal YbbB orthologs represent a bipartite version of bacterial tRNA 2-selenouridine synthase Methanothermococcus okinawensis