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Literature summary extracted from

  • Steiner, E.M.; Schneider, G.; Schnell, R.
    Binding and processing of beta-lactam antibiotics by the transpeptidase LdtMt2 from Mycobacterium tuberculosis (2017), FEBS J., 284, 725-741 .
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.2.B14 5,5'-dithio-bis-2-nitrobenzoic acid derivative, to 1.55 A resolution. The compound binds to the catalytic cysteine residue, Cys354, in both chains of the asymmetric unit Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
2.3.2.B14 C354A mutant does not display adduct formation with inhibitors faropenem or 6-aminopenicillanic acid Mycobacterium tuberculosis
2.3.2.B14 H336A no cysteine acylation by inhibitors can be detected in a 0-500-s time frame Mycobacterium tuberculosis
2.3.2.B14 H352A mutation does not show a decrease in the rate of the acylation reaction by inhibitors Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.B14 6-aminopenicillanic acid high degree of Cys354 modification, occurrence of a possible coupling reaction Mycobacterium tuberculosis
2.3.2.B14 amoxicillin no covalent adduct observed Mycobacterium tuberculosis
2.3.2.B14 biapenem high degree of Cys354 modification Mycobacterium tuberculosis
2.3.2.B14 doripenem high degree of Cys354 modification Mycobacterium tuberculosis
2.3.2.B14 ertapenem high degree of Cys354 modification Mycobacterium tuberculosis
2.3.2.B14 faropenem high degree of Cys354 modification, fast degradation following the initial acylation event Mycobacterium tuberculosis
2.3.2.B14 faropenem daloxate high degree of Cys354 modification, fast degradation following the initial acylation event Mycobacterium tuberculosis
2.3.2.B14 meropenem high degree of Cys354 modification Mycobacterium tuberculosis
2.3.2.B14 additional information the intact catalytic site is required for the acylation by beta-lactams Mycobacterium tuberculosis
2.3.2.B14 penicillin-G no covalent adduct observed Mycobacterium tuberculosis
2.3.2.B14 piperacillin high degree of Cys354 modification Mycobacterium tuberculosis
2.3.2.B14 pivmecillinam no covalent adduct observed Mycobacterium tuberculosis
2.3.2.B14 tebipenem high degree of Cys354 modification Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.B14 Mycobacterium tuberculosis I6Y9J2
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2.3.2.B14 Mycobacterium tuberculosis H37Rv I6Y9J2
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