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Literature summary extracted from

  • Galli, L.M.; Zebarjadi, N.; Li, L.; Lingappa, V.R.; Burrus, L.W.
    Divergent effects of porcupine and Wntless on WNT1 trafficking, secretion, and signaling (2016), Exp. Cell Res., 347, 171-183 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt]-L-serine Mus musculus the enzyme is an essential mediators of Wnt secretion and signaling CoA + [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine
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Organism

EC Number Organism UniProt Comment Textmining
2.3.1.250 Mus musculus Q9JJJ7
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt]-L-serine
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 Mus musculus CoA + [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine
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 ?
2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt]-L-serine the enzyme is an essential mediators of Wnt secretion and signaling Mus musculus CoA + [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.250 PORCN
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 Mus musculus
2.3.1.250 porcupine
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 Mus musculus

General Information

EC Number General Information Comment Organism
2.3.1.250 metabolism porcupine (PORCN) and Wntless (WLS) are essential mediators of Wnt secretion and signaling. PORCN and WLS form a complex. THes compete for binding to WNT1. Overexpression of PORCN promotes palmitoylation of WNT1 Mus musculus