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Literature summary extracted from

  • Xing, R.; Zhang, H.; Yuan, J.; Zhang, K.; Li, L.; Guo, H.; Zhao, L.; Zhang, C.; Li, S.; Gao, T.; Liu, Y.; Wang, L.
    Novel 6-substituted benzoyl and non-benzoyl straight chain pyrrolo[2,3-d]pyrimidines as potential antitumor agents with multitargeted inhibition of TS, GARFTase and AICARFTase (2017), Eur. J. Med. Chem., 139, 531-541 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.2 (S)-2-[2-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo [2,3-d]pyrimidin-6-yl)-acetylamino]-acetylamino]-pentanedioic acid
-
 Homo sapiens
2.1.2.2 (S)-2-[3-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo [2,3-d]pyrimidin-6-yl)-acetylamino]-propionylamino]-pentanedioic acid
-
 Homo sapiens
2.1.2.2 (S)-2-[4-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo [2,3-d]pyrimidin-6-yl)-acetylamino]-benzoylamino]-pentanedioic acid
-
 Homo sapiens
2.1.2.2 (S)-2-[4-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo [2,3-d]pyrimidin-6-yl)-acetylamino]-butyrylamino]-pentanedioic acid
-
 Homo sapiens
2.1.2.2 (S)-2-[5-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo [2,3-d]pyrimidin-6-yl)-acetylamino]-pentanoylamino]-pentanedioic acid
-
 Homo sapiens
2.1.2.2 (S)-2-[6-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo [2,3-d]pyrimidin-6-yl)-acetylamino]-hexanoylamino]-pentanedioic acid
-
 Homo sapiens
2.1.2.2 methotrexate
-
 Homo sapiens
2.1.2.2 pemetrexed
-
 Homo sapiens
2.1.2.3 (S)-2-[2-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo [2,3-d]pyrimidin-6-yl)-acetylamino]-acetylamino]-pentanedioic acid
-
 Homo sapiens
2.1.2.3 (S)-2-[3-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo [2,3-d]pyrimidin-6-yl)-acetylamino]-propionylamino]-pentanedioic acid
-
 Homo sapiens
2.1.2.3 (S)-2-[4-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo [2,3-d]pyrimidin-6-yl)-acetylamino]-benzoylamino]-pentanedioic acid
-
 Homo sapiens
2.1.2.3 (S)-2-[4-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo [2,3-d]pyrimidin-6-yl)-acetylamino]-butyrylamino]-pentanedioic acid
-
 Homo sapiens
2.1.2.3 (S)-2-[5-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo [2,3-d]pyrimidin-6-yl)-acetylamino]-pentanoylamino]-pentanedioic acid
-
 Homo sapiens
2.1.2.3 (S)-2-[6-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo [2,3-d]pyrimidin-6-yl)-acetylamino]-hexanoylamino]-pentanedioic acid
-
 Homo sapiens
2.1.2.3 methotrexate
-
 Homo sapiens
2.1.2.3 pemetrexed
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.2 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide Homo sapiens
-
 tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide
-
 ?
2.1.2.3 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide Homo sapiens
-
 tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.2 Homo sapiens
-
-
-
2.1.2.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.2 breast cancer cell
-
 Homo sapiens
-
2.1.2.2 colonic cancer cell
-
 Homo sapiens
-
2.1.2.2 KB cell
-
 Homo sapiens
-
2.1.2.2 MCF-7 cell
-
 Homo sapiens
-
2.1.2.2 nasopharyngeal carcinoma cell
-
 Homo sapiens
-
2.1.2.2 SW-620 cell
-
 Homo sapiens
-
2.1.2.3 breast cancer cell
-
 Homo sapiens
-
2.1.2.3 colonic cancer cell
-
 Homo sapiens
-
2.1.2.3 KB cell
-
 Homo sapiens
-
2.1.2.3 MCF-7 cell
-
 Homo sapiens
-
2.1.2.3 nasopharyngeal carcinoma cell
-
 Homo sapiens
-
2.1.2.3 SW-620 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.2 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide
-
 Homo sapiens tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide
-
 ?
2.1.2.3 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 Homo sapiens tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.2.2 GARFTase
-
 Homo sapiens
2.1.2.2 glycinamide ribonucleotide formyltransferase
-
 Homo sapiens
2.1.2.3 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
-
 Homo sapiens
2.1.2.3 AIRCARFTase
-
 Homo sapiens