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Literature summary extracted from

  • Kumar, A.; Bhowmick, K.; Vikramdeo, K.; Mondal, N.; Subbarao, N.; Dhar, S.
    Designing novel inhibitors against histone acetyltransferase (HAT xa0GCN5) of Plasmodium falciparum (2017), Eur. J. Med. Chem., 138, 26-37 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.48
-
 Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.48 (2R)-2-[2-(4-[[(3-methyl-1-oxo-1,2-dihydrobenzo[f]quinazolin-9-yl)methyl]amino]phenyl)-2-oxoethyl]pentanedioic acid
-
 Plasmodium falciparum
2.3.1.48 (2S)-2-(5-[[(3-methyl-1-oxo-1,2-dihydrobenzo[f]quinazolin-9-yl)methyl]amino]-1-oxo-1,3-dihydro-2H-isoindol-2-yl)pentanedioic acid ZINC36175770 Plasmodium falciparum
2.3.1.48 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione
-
 Plasmodium falciparum
2.3.1.48 2-hydroxy-6-pentadecylbenzoic acid
-
 Plasmodium falciparum
2.3.1.48 2-hydroxy-6-[(8E,11E)-pentadeca-8,11,14-trienyl]benzoic acid
-
 Plasmodium falciparum
2.3.1.48 2-hydroxy-6-[(E)-pentadec-8-enyl]benzoic acid
-
 Plasmodium falciparum
2.3.1.48 3'-O-(4-benzoylbenzoyl)adenosine 5'-triphosphate ZINC65731330 Plasmodium falciparum
2.3.1.48 4-[4-(3,4-dicarboxybenzamido)phenoxy]benzene-1,2-dicarboxylic acid ZINC03143991 Plasmodium falciparum
2.3.1.48 4-[4-(3,4-dimethylbenzamido)phenoxy]benzene-1,2-dicarboxylic acid
-
 Plasmodium falciparum
2.3.1.48 4-[4-(3-methylbenzamido)phenoxy]benzene-1,2-dicarboxylic acid ZINC09694266 Plasmodium falciparum
2.3.1.48 5-chloro-6-[([1-[(2R)-2-hydroxy-2-(6-methoxyquinolin-4-yl)ethyl]piperidin-4-yl]amino)methyl]-1,3-benzoxazol-2(3H)-one
-
 Plasmodium falciparum
2.3.1.48 6-[(4S)-5-(ethoxycarbonyl)-6-methyl-2-oxo-4-phenyl-3,4-dihydropyrimidin-1(2H)-yl]hexanoic acid ZINC14246093 Plasmodium falciparum
2.3.1.48 6-[(4S)-5-(ethoxycarbonyl)-6-methyl-2-oxo-4-[4-(trifluoromethoxy)phenyl]-3,4-dihydropyrimidin-1(2H)-yl]hexanoic acid ZINC40152345 Plasmodium falciparum
2.3.1.48 6-[(4S)-5-(ethoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl]hexanoic acid
-
 Plasmodium falciparum
2.3.1.48 6-[(4S)-5-[(benzyloxy)carbonyl]-4-([1,1'-biphenyl]-4-yl)-6-methyl-2-oxo-3,4-dihydropyrimidin-1(2H)-yl]hexanoic acid ZINC08829517 Plasmodium falciparum
2.3.1.48 C646
-
 Plasmodium falciparum
2.3.1.48 N-(2-fluoro-4-[[(1-hydroxy-3-methylbenzo[f]quinazolin-9-yl)methyl]amino]benzoyl)-L-glutamic acid
-
 Plasmodium falciparum
2.3.1.48 N-(4-[[(1-hydroxy-3-methylbenzo[f]quinazolin-9-yl)methyl]amino]cyclohexane-1-carbonyl)-L-glutamic acid
-
 Plasmodium falciparum
2.3.1.48 N-(4-[[(2-amino-4-hydroxyquinazolin-6-yl)methyl](formyl)amino]benzoyl)-L-glutamic acid
-
 Plasmodium falciparum
2.3.1.48 N-(4-[[(2-amino-4-oxo-3,4-dihydroquinazolin-6-yl)methyl](cyanomethyl)amino]benzoyl)-L-glutamic acid ZINC29250560 Plasmodium falciparum
2.3.1.48 N-(4-[[(2-amino-4-oxo-3,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino]benzoyl)-L-glutamic acid ZINC19217280 Plasmodium falciparum
2.3.1.48 N-(4-[[(2-amino-7-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino]benzoyl)-L-glutamic acid
-
 Plasmodium falciparum
2.3.1.48 N-(4-[[4-(2-amino-6-oxo-1,6-dihydropyrimidin-5-yl)benzene-1-sulfonyl]amino]benzoyl)-L-glutamic acid
-
 Plasmodium falciparum
2.3.1.48 N-[4-([[(6S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl]amino)benzoyl]-L-glutamic acid ZINC34633488 Plasmodium falciparum
2.3.1.48 N-[4-[(2-methyl-4-oxo-3,4-dihydroquinazoline-6-sulfonyl)amino]benzoyl]-L-glutamic acid
-
 Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.48 acetyl-CoA + [histone H3]-L-lysine14 Plasmodium falciparum
-
 CoA + [histone H3]-N6-acetyl-L-lysine14
-
 ?
2.3.1.48 acetyl-CoA + [histone H3]-L-lysine9 Plasmodium falciparum
-
 CoA + [histone H3]-N6-acetyl-L-lysine9
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Plasmodium falciparum Q8IB67 isolate 3D7
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.48 Ni-NTA column chromatography and Superdex S200 gel filtration Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + [histone H3]-L-lysine14
-
 Plasmodium falciparum CoA + [histone H3]-N6-acetyl-L-lysine14
-
 ?
2.3.1.48 acetyl-CoA + [histone H3]-L-lysine9
-
 Plasmodium falciparum CoA + [histone H3]-N6-acetyl-L-lysine9
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.48 ? x * 50000, SDS-PAGE Plasmodium falciparum

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 Gcn5
-
 Plasmodium falciparum
2.3.1.48 GCN5 N acetyltransferase 5
-
 Plasmodium falciparum
2.3.1.48 HAT
-
 Plasmodium falciparum