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Literature summary extracted from

  • Koyama, M.; Shirahata, T.; Hirashima, R.; Kobayashi, Y.; Itoh, T.; Fujiwara, R.
    Inhibition of UDP-glucuronosyltransferase (UGT)-mediated glycyrrhetinic acid 3-O-glucuronidation by polyphenols and triterpenoids (2017), Drug Metab. Pharmacokinet., 32, 218-223 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 alisol B
-
Homo sapiens
2.4.1.17 alisol B acetate
-
Homo sapiens
2.4.1.17 catechin
-
Homo sapiens
2.4.1.17 isoliquiritigenin
-
Homo sapiens
2.4.1.17 additional information not inhibited by glabridin, liquiritigenin, licochalcone A, isoliquiritin, astragaloside IV, alisol A, ergosterol, ginsenoside Rb1, E-arasone, saikosaponin A, linarin, luteolin, luteolin-7-O-glucoside, perilaldehyde, beta-eudesmol, apigenin 7-O-glucoside, betulinic acid, and oleanolic acid Homo sapiens
2.4.1.17 protopanaxadiol competitive inhibition Homo sapiens
2.4.1.17 rosmarinic acid
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mg2+ 4 mM used in assay conditions Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 glycyrrhetinic acid + UDP-glucuronate
-
Homo sapiens UDP + glycyrrhetinic acid-3-O-glucuronide
-
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Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase
-
Homo sapiens
2.4.1.17 UGT
-
Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.17 0.0359
-
protopanaxadiol at pH 7.4 and 37°C Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.1.17 0.0592
-
at pH 7.4 and 37°C Homo sapiens protopanaxadiol
2.4.1.17 0.0964
-
at pH 7.4 and 37°C Homo sapiens isoliquiritigenin
2.4.1.17 0.125
-
at pH 7.4 and 37°C Homo sapiens rosmarinic acid
2.4.1.17 0.16
-
at pH 7.4 and 37°C Homo sapiens alisol B
2.4.1.17 0.163
-
at pH 7.4 and 37°C Homo sapiens alisol B acetate
2.4.1.17 0.164
-
at pH 7.4 and 37°C Homo sapiens catechin